Radicicol
Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
Purity: ≥98%
Biological Activity
Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90.
Lee et al.
Mol.Cell.Endocrinol., 2002;188:47 -
Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis.
Oikawa et al.
Eur.J.Pharmacol., 1993;241:221 -
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Schulte et al.
Mol.Endocrinol., 1999;13:1435
Product Datasheets
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Citations for Radicicol
The citations listed below are publications that use Tocris products. Selected citations for Radicicol include:
2 Citations: Showing 1 - 2
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Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity.
Authors: Ginzberg Et al.
Elife 2018;7
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BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation.
Authors: Stecklein Et al.
Proc Natl Acad Sci U S A 2012;109:13650
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