Home / Non-selective Dopamine Receptor Antagonists / Raclopride

Raclopride

Catalog #: 1810
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1810/10
1810/50
Raclopride | CAS No. 84225-95-6 | Non-selective Dopamine Receptor Antagonists
1 Image
Description: Potent and selective D2 and D3 antagonist

Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
347.24
Formula:
C15H20Cl2N2O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
84225-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Animal pharmacology of raclopride, a selective DA D2 antagonist.
    Hall et al.
    Psychopharmacol.Ser., 1989;7:123
  2. The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions.
    Ogren et al.
    Psychopharmacology, 1986;90:287
  3. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Raclopride

The citations listed below are publications that use Tocris products. Selected citations for Raclopride include:

12 Citations: Showing 1 - 10

  1. Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
    Authors: Verharen Et al.
    Neuropsychopharmacology  2019;44:2195
  2. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
    Authors: Lassus Et al.
    Sci Rep  2018;8:17461
  3. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  4. The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci  2015;9:331
  5. Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs.
    Authors: Heath Et al.
    Psychopharmacology (Berl)  2015;232:4043
  6. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
    Authors: Jiang Et al.
    Psychopharmacology (Berl)  2015;18
  7. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology  2014;39:569
  8. Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    J Neurosci  2014;306:R138
  9. DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  10. DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.
    Authors: Ogata Et al.
    J Comp Neurol  2012;520:4032

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for Raclopride

There are currently no reviews for this product. Be the first to review Raclopride and earn rewards!

Have you used Raclopride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.