rac-CCT 250863

Catalog #: 4546 Datasheet / COA / SDS

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4546/5

rac-CCT 250863 | CAS No. 1364269-06-6 | Nek2 Kinase Inhibitors

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Description: Potent Nek2 inhibitor

Chemical Name: 4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide

Purity: ≥98%

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Biological Activity

rac-CCT 250863 is a potent Nek2 inhibitor (IC₅₀ = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

Technical Data

M.Wt:

490.54

Formula:

C₂₄H₂₅F₃N₄O₂S

Solubility:

Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1364269-06-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.
Innocenti et al.
J.Med.Chem., 2012;55:3228

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