(R)-(-)-Rolipram

Catalog #: 1349
1 Citation Datasheet / COA / SDS

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(R)-(-)-Rolipram | CAS No. 85416-75-7 | Phosphodiesterase Inhibitors

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Description: PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)

Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity

(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.

Racemate and S-enantiomer also available.

Technical Data

M.Wt:

275.35

Formula:

C₁₆H₂₁NO₃

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

85416-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
Ohsawa et al.
Jpn.J.Pharmacol., 1998;77:147
Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
Owens et al.
Biochem.J., 1997;326:53
Stereospecific binding of the antidepressant rolipram to brain protein structures.
Schneider et al.
Eur.J.Pharmacol., 1986;127:105

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Citation for (R)-(-)-Rolipram

The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:

1 Citation: Showing 1 - 1

Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Authors: Boomkamp Et al.
Br J Pharmacol 2014;171:2385

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