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PZM21

Catalog #: 7218 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7218/50
7218/10
PZM21 | CAS No. 1997387-43-5 | mu Opioid Receptor Agonists
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Description: Selective μ receptor agonist

Chemical Name: N-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]urea

Purity: ≥98%

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Biological Activity

PZM21 is a selective μ receptor agonist (EC50 = 4.6 nM). PZM21 has been reported to exhibit bias for the Gi signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

Technical Data

M.Wt:
361.5
Formula:
C19H27N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1997387-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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