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PPY A

Catalog #: 4730 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4730/10
4730/50
PPY A | CAS No. 875634-01-8 | Abl Kinase Inhibitors
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Description: Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide

Purity: ≥98%

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Biological Activity

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Technical Data

M.Wt:
372.42
Formula:
C22H20N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
875634-01-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Crystal structure of the T315I mutant of AbI kinase.
    Zhou et al.
    Chem.Biol.Drug.Des., 2007;70:171
  2. Inhibitors of ABL and the ABL-T315I mutation.
    Noronha et al.
    Curr.Top.Med.Chem., 2008;8:905

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