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PPNDS

Catalog #: 1309
1 Citation Datasheet / COA / SDS

Discontinued Product

1309 has been discontinued.
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PPNDS | CAS No. 1021868-77-8 | P2X Receptor Antagonists
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Description: Potent and selective P2X1 antagonist

Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PPNDS is a potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.

Technical Data

M.Wt:
694.36
Formula:
C18H11N4Na4O14PS2
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at -20°C
CAS No:
1021868-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors.
    Lambrecht et al.
    Eur.J.Pharmacol., 2000;387:R19

Product Datasheets

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Citation for PPNDS

The citations listed below are publications that use Tocris products. Selected citations for PPNDS include:

1 Citation: Showing 1 - 1

  1. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.
    Authors: Madoux Et al.
    Biopolymers  2014;102:396

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