PLP (139-151)
Purity: ≥95%
Biological Activity
PLP (139-151) is a synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta.
Jana M, Mondal S, Gonzalez F, Pahan K
J Biol Chem, 2012;287(41):34134-48. -
Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.
Tuohy et al.
J.Immunol., 1989;142:1523 -
Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein.
Sobel et al.
J.Neuropathol.Exp.Neurol., 1990;49:468 -
Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides.
Kuchroo et al.
Pathobiology., 1991;59:305
Product Datasheets
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Citations for PLP (139-151)
The citations listed below are publications that use Tocris products. Selected citations for PLP (139-151) include:
3 Citations: Showing 1 - 3
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A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model.
Authors: Arima Et al.
Elife 2015;4
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Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis.
Authors: Mondal Et al.
J Clin Cell Immunol 2012;3:124
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Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.
Authors: Jana Et al.
J Biol Chem 2012;287:34134
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