PHPS1 sodium salt
Chemical Name: 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt
Purity: ≥98%
Biological Activity
PHPS1 sodium salt is a Shp2 (PTPN11) inhibitor (IC50 = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.
Hellmuth et al.
Proc.Natl.Acad.Sci.U.S.A, 2008;105:7275 -
The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.
Ahrendsen et al.
J.Neurosci., 2018;38:787 -
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender et al.
Nat.Commun., 2018;9:3259
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Citation for PHPS1 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for PHPS1 sodium salt include:
1 Citation: Showing 1 - 1
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Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p.
Authors: Dinko Et al.
Cell Mol Neurobiol 2023;43:1975-1988
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