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Pertussis Toxin

Catalog #: 3097
21 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3097/50U
Pertussis Toxin | CAS No. 70323-44-3 | G Protein (Heterotrimeric) Inhibitors
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Description: Catalyzes ADP-ribosylation of Gi, Go and Gt
Product Details
Citations (21)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling. Pertussis Toxin protects against ischemic stroke in a mouse model of permanent middle cerebral artery occlusion. Pertussis Toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an experimental autoimmune encephalomyelitis mouse model.

Technical Data

Storage:
Store at +4°C
CAS No:
70323-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Hierarchical patterning modes orchestrate hair follicle morphogenesis
    JD Glover, KL Wells, F Matthäus, KJ Painter, W Ho, J Riddell, JA Johansson, MJ Ford, CAB Jahoda, V Klika, RL Mort, DJ Headon
    PLoS Biol., 2017;15(7):e2002117.
  2. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
    Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg M
    J Biol Chem, 2013;288(46):32979-90.
  3. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice
    J Shu, X He, H Li, X Liu, X Qiu, T Zhou, P Wang, X Huang
    J Immunol Res, 2018;2018(0):5083797.
  4. Cutting edge: Intravascular staining redefines lung CD8 T cell responses.
    Anderson, Kristin, Sung, Heungsup, Skon, Cara N, Lefrancois, Leo, Deisinger, Angela, Vezys, Vaiva, Masopust, David
    J Immunol, 2012;189(6):2702-6.
  5. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
    Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
    J Biol Chem, 2014;289(26):18569-81.
  6. C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
    CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
    Elife, 2018;7(0):.
  7. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.

    Proc Natl Acad Sci U S A, 2012;109(52):21492-7.
  8. Succinate, increased in metabolic syndrome, activates GPR91 receptor signaling in urothelial cells
    AH Mossa, MV Flores, PG Cammisotto, L Campeau
    Cell. Signal., 2017;0(0):.
  9. Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm, Bombyx mori, dually couples to the G(q) and G(s) signaling cascades.
    Yang, Jingwen, Huang, Haishan, Yang, Huipeng, He, Xiaobai, Jiang, Xue, Shi, Ying, Alatangaole, Damirin, Shi, Liangen, Zhou, Naiming
    J Biol Chem, 2013;288(17):11662-75.
  10. Experimental autoimmune uveoretinitis (EAU)-related tissue damage and angiogenesis is reduced in CCL2(-)/(-)CX(3)CR1gfp/gfp mice.
    Zhao J, Chen M, Xu H
    Invest Ophthalmol Vis Sci, 2015;55(11):7572-82.
  11. CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines.
    Al-Alwan L, Chang Y, Rousseau S, Martin J, Eidelman D, Hamid Q
    J Immunol, 2015;193(3):1416-26.
  12. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Butschkau, Antje, Wagner, Nana-Mar, Genz, Berit, Vollmar, Brigitte
    PLoS ONE, 2014;9(12):e113554.
  13. Indentification of the predominant substrate for ADP-ribosylation by islet activating protein.
    Bokoch et al.
    J.Biol.Chem., 1983;258:2072
  14. ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin.
    Barbieri and Cortina
    Infect.Immun., 1988;56:1934
  15. G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa.
    Casey et al.
    Biochemistry, 1989;28:611

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Citations for Pertussis Toxin

The citations listed below are publications that use Tocris products. Selected citations for Pertussis Toxin include:

21 Citations: Showing 1 - 10

  1. Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2.
    Authors: Hu Et al.
    EBioMedicine  2022;86:104333
  2. Mitochondrial remodeling and ischemic protection by G protein�coupled receptor 35 agonists.
    Authors: Wyant Et al.
    Science  2022;377:621
  3. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
    Authors: Nepomuceno Et al.
    Front Pharmacol  2018;9:157
  4. Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
    Authors: O'Neill & Sylantyev
    Exp Biol Med (Maywood)  2018;243:1046
  5. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2.
    Authors: Zhao Et al.
    Molecules  2018;23
  6. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
    Authors: Li Et al.
    Theranostics  2017;7:4671
  7. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
    Authors: Yuan Et al.
    Am J Physiol Heart Circ Physiol  2016;7:11024
  8. A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocy. green dye.
    Authors: Sim Et al.
    Int J Cancer  2015;8:1479
  9. Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica.
    Authors: Jones Et al.
    Acta Neuropathol Commun  2015;3:28
  10. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci  2015;136:E219
  11. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Dis Model Mech  2015;112:6497
  12. The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis.
    Authors: Crawford Et al.
    PLoS One  2015;10:e0122093
  13. Protein z exerts pro-angiogenic effects and upregulates CXCR4.
    Authors: Butschkau Et al.
    PLoS One  2014;9:e113554
  14. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
    Authors: Boldison Et al.
    J Immunol  2014;192:4541
  15. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death.
    Authors: Rimmerman Et al.
    Cell Death Dis  2013;4:e949
  16. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
    Authors: Cheng Et al.
    Proc Natl Acad Sci U S A  2012;302:H675
  17. Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.
    Authors: Wydeven Et al.
    Proc Natl Acad Sci U S A  2012;109:21492
  18. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
    Authors: Park Et al.
    Neuron  2011;31:18433
  19. Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
    Authors: Schutsky Et al.
    J Neurosci  2011;31:14172
  20. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  21. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation.
    Authors: Nagaraja Et al.
    Nat Commun  1999;127:1099

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Fast delivery and great quality
By Anonymous on 07/17/2017

It was used to block gpcr response before hitting the cells with the ligand for receptor of interest

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