Orlistat
Chemical Name: N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Purity: ≥98%
Biological Activity
Orlistat is a hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo. Orlistat inhibits neutral lipid lipase LIPE and dose-dependently reduces α-synuclein-positive cytoplasmic inclusions in α-synuclein-expressing neuroblastoma cell lines.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.
Hadvary et al.
J.Biol.Chem., 1991;266:2021 -
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.
Kridel et al.
Cancer Res., 2004;64:2070 -
Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects.
Enc et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2008;296:G482
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Citations for Orlistat
The citations listed below are publications that use Tocris products. Selected citations for Orlistat include:
6 Citations: Showing 1 - 6
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Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK.
Authors: Nobuya Et al.
iScience 2021;24:102963
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Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.
Authors: Argueta Et al.
Front Physiol 2019;10:704
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OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
Authors: Xiao Et al.
Elife 2018;7
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A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
Authors: Musella
Sci Rep 2017;7(1):7363
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Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
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The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.
Authors: Breunig Et al.
Front Neurosci 2010;30:8965
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