ONO 2506
Chemical Name: (2R)-2-Propyloctanoic acid
Biological Activity
ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice.
Kato et al.
Brain Res., 2004;1030:66 -
Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early
Tateishi et al.
J.Cereb.Blood Flow Metab., 2002;22:723 -
Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.
Mori et al.
J.Pharmacol.Exp.Ther., 2006;318:571
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Citation for ONO 2506
The citations listed below are publications that use Tocris products. Selected citations for ONO 2506 include:
1 Citation: Showing 1 - 1
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Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development.
Authors: Hao Et al.
Front Cell Neurosci 2017;11:42
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