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Oligomycin A

Catalog #: 4110
10 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4110/5
Oligomycin A | CAS No. 579-13-5 | Other ATPase Inhibitors
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Description: Inhibitor of mitochondrial ATPase

Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione

Purity: ≥98%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data

M.Wt:
791.06
Formula:
C45H74O11
Solubility:
Soluble to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
579-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
    RS Banh, C Iorio, R Marcotte, Y Xu, D Cojocari, AA Rahman, J Pawling, W Zhang, A Sinha, CM Rose, M Isasa, S Zhang, R Wu, C Virtanen, T Hitomi, T Habu, SS Sidhu, A Koizumi, SE Wilkins, T Kislinger, SP Gygi, CJ Schofield, JW Dennis, BG Wouters, BG Neel
    Nat. Cell Biol, 2016;18(7):803-13.
  2. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
    Salomon et al.
    Chem.Biol., 2001;8:71

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Citations for Oligomycin A

The citations listed below are publications that use Tocris products. Selected citations for Oligomycin A include:

10 Citations: Showing 1 - 10

  1. Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms.
    Authors: Kurt I Et al.
    Cell Rep  2021;34:108750
  2. Investigating the Dynamic Changes in iNKT Cell Metabolic Profiles During Development.
    Authors: Hongbo Et al.
    Methods Mol Biol  2021;2388:181-192
  3. The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments.
    Authors: Bernd Et al.
    Int J Mol Sci  2021;22
  4. Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.
    Authors: P Darrell Et al.
    Elife  2021;10
  5. Cellular uptake of protic ruthenium complexes is influenced by pH dependent passive diffusion and energy dependent efflux.
    Authors: Yonghyun Et al.
    J Inorg Biochem  2020;203:110922
  6. Metabolic Profiling of Single Cancer Cells Using Mitochondrial ATP Probes.
    Authors: Roland Et al.
    STAR Protoc  2020;1:100048
  7. Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
    Authors: Depaoli Et al.
    Cell Rep  2018;25:501
  8. Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
    Authors: Shin Et al.
    Cell Metab  2017;26:764
  9. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
    Authors: Banh Et al.
    Nat Cell Biol  2016;18:803
  10. The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing.
    Authors: Roland C Et al.
    Mol Inform  2013;32:47-63

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