Olanzapine
Chemical Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Purity: ≥99%
Biological Activity
Olanzapine is an antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303 -
The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.
Moore et al.
J.Pharmacol.Exp.Ther., 1992;262:545 -
Radioreceptor binding profile of the atypical antipsychotic olanz.
Bymaster et al.
Neuropsychopharmacology, 1996;14:87
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Olanzapine
The citations listed below are publications that use Tocris products. Selected citations for Olanzapine include:
4 Citations: Showing 1 - 4
-
Serotonin 2A (5-HT2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells.
Authors: Mitradas M Et al.
Sci Rep 2020;10:21675
-
Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
Authors: Joshi and Panicker
Eneuro 2019;5
-
A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
Authors: Pérez-G?mez Et al.
Nat Commun 2018;9:5272
-
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
Nat Methods 2015;40:766
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Olanzapine
There are currently no reviews for this product. Be the first to review Olanzapine and earn rewards!
Have you used Olanzapine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image