Home / DNA-dependent Protein Kinase Inhibitors / NU 7026

NU 7026

Catalog #: 2828
14 Citations Datasheet / COA / SDS
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2828/10
2828/50
NU 7026 | CAS No. 154447-35-5 | DNA-dependent Protein Kinase Inhibitors
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Description: Selective DNA-PK inhibitor

Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one

Purity: ≥98%

Product Details
Citations (14)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Technical Data

M.Wt:
281.31
Formula:
C17H15NO3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
154447-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DEK is required for homologous recombination repair of DNA breaks
    EA Smith, B Gole, NA Willis, R Soria, LM Starnes, EF Krumpelbec, AG Jegga, AM Ali, H Guo, AR Meetei, PR Andreassen, F Kappes, LM Vinnedge, JA Daniel, R Scully, L Wiesmüller, SI Wells
    Sci Rep, 2017;7(0):44662.
  2. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I.
    Veuger et al.
    Cancer Res., 2003;63:6008
  3. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase.
    Amrein et al.
    J.Pharmacol.Exp.Ther., 2007;321:848

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Citations for NU 7026

The citations listed below are publications that use Tocris products. Selected citations for NU 7026 include:

14 Citations: Showing 1 - 10

  1. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
    Authors: Jaiswal Et al.
    EMBO J  2017;36:2161
  2. Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
    Authors: Nakahara Et al.
    Chembiochem  2015;89:5040
  3. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
    Authors: Allen Et al.
    Front Oncol  2015;5:260
  4. Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
    Authors: You Et al.
    Elife  2015;4
  5. Spatio-temporal regulation of RAG2 following genotoxic stress.
    Authors: Rodgers Et al.
    DNA Repair (Amst)  2015;27:19
  6. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One  2015;10:e0145744
  7. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
    Authors: Yousefzadeh Et al.
    PLoS Genet  2014;10:e1004654
  8. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  9. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  10. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.
    Authors: Petruccelli Et al.
    Mol Cancer Ther  2013;12:1591

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