Home / Protein Tyrosine Phosphatase Inhibitors / NSC 87877

NSC 87877

Catalog #: 2613
8 Citations Datasheet / COA / SDS

Discontinued Product

2613 has been discontinued.
View all Protein Tyrosine Phosphatase Inhibitors products.
NSC 87877 | CAS No. 56990-57-9 | Protein Tyrosine Phosphatase Inhibitors
1 Image
Description: Potent inhibitor of shp2 and shp1 PTP

Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

Purity: ≥98%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data

M.Wt:
459.45
Formula:
C19H13N3O7S2
Solubility:
Soluble to 50 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
56990-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner.
    Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse S, Philippe M, Benzakour O
    Blood, 2012;120(25):5073-83.
  2. Antagonism of VEGF-A-induced increase in vascular permeability by an integrin alpha3beta1-Shp-1-cAMP/PKA pathway.
    Kim S, Cho Y, Kim H, Oh J, Ahn E, Ko H, Hwang B, Lee S, Cho Y, Kim Y, Stetler-Stevenson W, Seo D
    Blood, 2012;120(24):4892-902.
  3. Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes.
    Soong, Joanne, Scott, Glynis
    J Cell Sci, 0;126(0):688-95.
  4. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
    Chen et al.
    Mol.Pharmacol., 2006;70:562
  5. Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2.
    Zhao et al.
    Dev.Neurobiol., 2007;67:1789
  6. hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
    Redonde et al.
    J.Thromb.Haemost., 2007;5:2476
  7. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2
    FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li, B Nowlan, GM Williams, E Jacobson, GW Osborne, FA Meunier, SM Taylor, KE Campbell, KP MacDonald, JP Levesque, TM Woodruff, MJ Ruitenberg
    JCI Insight, 2019;4(9):.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for NSC 87877

The citations listed below are publications that use Tocris products. Selected citations for NSC 87877 include:

8 Citations: Showing 1 - 8

  1. Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
    Authors: Zhang and Lu
    J Biol Chem  2017;292:15481
  2. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
    Authors: Kim Et al.
    Cell  2017;168:1053
  3. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
    Authors: Taylor Et al.
    Immunity  2016;44:274
  4. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
    Authors: Zhang Et al.
    J Biol Chem  2016;291:18856
  5. Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase.
    Authors: Pinzon-Guzman Et al.
    Int J Cancer  2015;55:152
  6. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.
    Authors: Quintanar-Audelo Et al.
    J Biol Chem  2011;286:23102
  7. Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.
    Authors: Abeyweera Et al.
    J Cell Biol  2011;192:675
  8. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells.
    Authors: Fragale Et al.
    J Immunol  2011;186:1951

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NSC 87877

There are currently no reviews for this product. Be the first to review NSC 87877 and earn rewards!

Have you used NSC 87877?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.