NS 3861

Catalog #: 4831 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4831/5
4831/25

NS 3861 | CAS No. 216853-60-0 | Additional Nicotinic Receptor Agonists

1 Image

Description: α3β2 full agonist; also α3β4 partial agonist

Chemical Name: 3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate

Purity: ≥98%

View All Products for Additional Nicotinic Receptor Agonists

Product Details

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NS 3861 is a α3β2 full agonist (EC₅₀ = 1.6 μM). Also α3β4 partial agonist (EC₅₀ = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (K_i values are 0.62, 7.8, 25 and 55 nM respectively).

Technical Data

M.Wt:

400.29

Formula:

C₁₂H₁₄BrNS.C₄H₄O₄

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

216853-60-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.
Harpsøe et al.
J.Biol.Chem., 2013;288:2559

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NS 3861

There are currently no reviews for this product. Be the first to review NS 3861 and earn rewards!

Have you used NS 3861?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.