NNC 711
Chemical Name: 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
Purity: ≥99%
Biological Activity
NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Borden et al.
Eur.J.Pharmacol., 1994;269:219 -
NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization.
Suzdak et al.
Eur.J.Pharmacol., 1992;224:189 -
Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor.
O'Connell et al.
Eur.J.Pharmacol., 2001;424:37
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Citations for NNC 711
The citations listed below are publications that use Tocris products. Selected citations for NNC 711 include:
4 Citations: Showing 1 - 4
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A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.
Authors: Kersanté Et al.
Anesthesiology 2013;591:2429
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Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.
Authors: Samoudi Et al.
PLoS One 2012;7:e29308
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Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Authors: Yoshizumi Et al.
Pain 2012;116:1347
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Glutamate uptake triggers transporter-mediated GABA release from astrocytes.
Authors: Héja Et al.
J Physiol 2009;4:e7153
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