NNC 26-9100
Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Purity: ≥99%
Biological Activity
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.
Liu et al.
J.Med.Chem., 1998;41:4693 -
2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity.
Liu et al.
Curr.Pharm.Des., 1999;5:255
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Citation for NNC 26-9100
The citations listed below are publications that use Tocris products. Selected citations for NNC 26-9100 include:
1 Citation: Showing 1 - 1
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Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats.
Authors: Honda Et al.
Urology 2012;80:1391000000000
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