NGI 1
Chemical Name: 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
Purity: ≥98%
Biological Activity
NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.
Puschnik et al.
Cell Rep., 2017;21:3032 -
Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors.
Lopez-Sambrooks et al.
Cancer Res., 2018;78:5094 -
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.
Lopez-Sambrooks et al.
Nat.Chem.Biol., 2016;12:1023
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