NFAT inhibitor, Cell Permeable

Biological Activity

NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice.
   Noguchi et al.
   Nat.Med., 2004;10:305
2. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.
   Elloumi et al.
   PLoS One, 2012;7:e34172

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