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NF 157

Catalog #: 2450
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2450/10
NF 157 | CAS No. 104869-26-3 | P2X Receptor Antagonists
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Description: Selective P2Y11 and P2X1 antagonist

Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Purity: ≥90%

Product Details
Citations (12)
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Biological Activity

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Technical Data

M.Wt:
1437.08
Formula:
C49H28F2N6Na6O23S6
Solubility:
Soluble to 5 mg/ml in water and to 10 mg/ml in DMSO
Purity:
≥90%
Storage:
Desiccate at RT
CAS No:
104869-26-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NF 157

The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:

12 Citations: Showing 1 - 10

  1. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  2. Antagonism of P2Y11 receptor (P2Y11R) protects epidermal stem cells against UV-B irradiation.
    Authors: Wu Et al.
    Am J Transl Res  2019;11:4738
  3. Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
    Authors: Kinoshita Et al.
    EBioMedicine  2018;32:72
  4. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
    Authors: Avanzato Et al.
    Scientific Reports  2016;6:32602
  5. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
    Authors: Ledderose Et al.
    J Infect Dis  2016;213:456
  6. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  7. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  8. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  9. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect  2014;3:e62
  10. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787

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