Necrostatin-1

Catalog # Availability Size / Price Qty
2324/50
2324/10
Necrostatin-1 | CAS No. 4311-88-0 | RIP Kinase Inhibitors
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Description: RIP1 kinase inhibitor; inhibits necroptosis

Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Technical Data

M.Wt:
259.33
Formula:
C13H13N3OS
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
4311-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
    SW Alvarez, VO Sviderskiy, EM Terzi, T Papagianna, AL Moreira, S Adams, DM Sabatini, K Birsoy, R Possemato
    Nature, 2017;551(7682):639-643.
  2. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death
    M Lötzerich, PS Roulin, K Boucke, R Witte, O Georgiev, UF Greber
    Cell Death Dis, 2018;9(3):272.
  3. DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death
    B Thibault, L Genre, A Le Naour, C Broca, E Mery, G Vuagniaux, JP Delord, N Wiedemann, B Couderc
    Sci Rep, 2018;8(1):17862.
  4. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
    J Transl Med, 2017;15(1):123.
  5. Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.
    Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T
    J Immunol, 2014;193(2):879-88.
  6. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
    Degterev et al.
    Nat.Chem.Biol., 2005;1:112
  7. Identification of RIP1 kinase as a specific cellular target of necroSTAT.
    Degterev et al.
    Nat.Chem.Biol., 2008;4:313

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Citations for Necrostatin-1

The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:

4 Citations: Showing 1 - 4

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