Necrostatin-1

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
   SW Alvarez, VO Sviderskiy, EM Terzi, T Papagianna, AL Moreira, S Adams, DM Sabatini, K Birsoy, R Possemato
   Nature, 2017;551(7682):639-643.
2. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death
   M Lötzerich, PS Roulin, K Boucke, R Witte, O Georgiev, UF Greber
   Cell Death Dis, 2018;9(3):272.
3. DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death
   B Thibault, L Genre, A Le Naour, C Broca, E Mery, G Vuagniaux, JP Delord, N Wiedemann, B Couderc
   Sci Rep, 2018;8(1):17862.
4. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
   HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
   J Transl Med, 2017;15(1):123.
5. Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.
   Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T
   J Immunol, 2014;193(2):879-88.
6. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
   Degterev et al.
   Nat.Chem.Biol., 2005;1:112
7. Identification of RIP1 kinase as a specific cellular target of necroSTAT.
   Degterev et al.
   Nat.Chem.Biol., 2008;4:313

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