NCL 00017509
Chemical Name: 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Purity: ≥97%
Biological Activity
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.
Lebraud et al.
Org.Biomol.Chem., 2014;12:141
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for NCL 00017509
The citations listed below are publications that use Tocris products. Selected citations for NCL 00017509 include:
1 Citation: Showing 1 - 1
-
NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.
Authors: Zhang Et al.
Nat Commun. 2021;12:4536
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NCL 00017509
There are currently no reviews for this product. Be the first to review NCL 00017509 and earn rewards!
Have you used NCL 00017509?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
