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NBC 19

Catalog #: 6722 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6722/10
NBC 19 | CAS No. 2068818-75-5 | Inflammasomes Inhibitors
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Description: Potent NLRP3 inflammasome inhibitor

Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

Technical Data

M.Wt:
491.64
Formula:
C24H26BCl3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2068818-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Manchester.

Background References

  1. Boron-based inhibitors of the NLRP3 inflammasome.
    Baldwin et al.
    Cell Chem.Biol., 2017;24:1321
  2. Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
    Redondo-Castro et al.
    Sci.Rep., 2018;8:5667

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