Narciclasine
Chemical Name: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity: ≥98%
Biological Activity
Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.
Dumont et al.
Neoplasia, 2007;9:766 -
Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents.
Ingrassia et al.
J.Med.Chem., 2009;52:1100 -
Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells.
Lefranc et al.
Mol.Cancer Ther., 2009;8:1739
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Citation for Narciclasine
The citations listed below are publications that use Tocris products. Selected citations for Narciclasine include:
1 Citation: Showing 1 - 1
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The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Authors: Duman Et al.
Elife 2019;8
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