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Mycophenolate mofetil

Catalog #: 4102
1 Citation Datasheet / COA / SDS
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4102/50
Mycophenolate mofetil | CAS No. 128794-94-5 | Dehydrogenase Inhibitors
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Description: Inosine monophosphate dehydrogenase (IMPDH) inhibitor

Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

Technical Data

M.Wt:
433.49
Formula:
C23H31NO7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
128794-94-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF).
    Allison and Eugui
    Clin.Transplant., 1996;10:77
  2. In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil.
    Roos et al.
    J.Pharm.Exp.Ther., 2007;321:583

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Citation for Mycophenolate mofetil

The citations listed below are publications that use Tocris products. Selected citations for Mycophenolate mofetil include:

1 Citation: Showing 1 - 1

  1. Modulation of immunosuppressant drug treatment to improve SARS-CoV-2 vaccine efficacy in mice.
    Authors: Fikri Y Et al.
    Vaccine  2022;40:854-861

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