MRS 1754
Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Purity: ≥98%
Biological Activity
MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
Kim et al.
J.Med.Chem., 2000;43:1165 -
[3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors.
Ji et al.
Biochem.Pharmacol., 2001;61:657 -
Adenosine receptor activation ameliorates type I diabetes.
Nemeth et al.
FASEB J., 2007;21:2380
Product Datasheets
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Citations for MRS 1754
The citations listed below are publications that use Tocris products. Selected citations for MRS 1754 include:
16 Citations: Showing 1 - 10
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Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
Authors: Liu Et al.
Brain Res 2018;1700:47
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Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.
Authors: Asano
Scientific Reports 2017;7:40214
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An Adenosine Receptor for Olfaction in Fish.
Authors: Wakisaka Et al.
Curr Biol 2017;27:1437
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Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
Authors: Ledderose Et al.
Purinergic Signalling 2016;
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Anti-inflammatory effects of adenosine N1-oxide.
Authors: Kohno Et al.
Am J Physiol Lung Cell Mol Physiol 2015;12:2
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Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain.
Authors: Lemos Et al.
Purinergic Signal 2015;11:561
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Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
Authors: Welihinda and Amento
J Inflamm (Lond) 2014;11:37
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Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
Authors: He Et al.
FASEB J 2013;27:3446
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Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
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Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
Authors: Kan Et al.
J Virol 2012;86:10338
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IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
Authors: Hua Et al.
PLoS One 2011;6:e24947
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Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury.
Authors: Pedroza Et al.
Mol Vis 2011;6:e22667
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Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection.
Authors: Zhan Et al.
Am J Physiol Heart Circ Physiol 2011;301:H1183
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Adenosine can mediate its actions through generation of reactive oxygen species.
Authors: Gebremedhin Et al.
J Cereb Blood Flow Metab 2010;30:1777
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Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
Authors: Yu Et al.
Am J Respir Crit Care Med 2009;297:L785
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Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.
Authors: Wolk Et al.
PLoS One 2008;178:969
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