MRS 1334
Chemical Name: 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
Purity: ≥98%
Biological Activity
MRS 1334 is a potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Role and Function of A2A and A? Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis
A Ravani, F Vincenzi, A Bortoluzzi, M Padovan, S Pasquini, S Gessi, S Merighi, PA Borea, M Govoni, K Varani
Int J Mol Sci, 2017;18(4):. -
New potent and selective human adenosine A3 receptor antagonists.
Baraldi and Borea
TiPS, 2000;21:456 -
Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.
Corriden et al.
EMBO.Rep., 2013;14:726 -
Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Li et al.
J.Med.Chem., 1998;41:3186
Product Datasheets
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Citations for MRS 1334
The citations listed below are publications that use Tocris products. Selected citations for MRS 1334 include:
6 Citations: Showing 1 - 6
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Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis.
Authors: Alsharif Et al.
Vascul Pharmacol 2015;71:201
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Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.
Authors: Corriden Et al.
Nat Commun 2013;14:726
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Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
Authors: Lee Et al.
EMBO Rep 2012;63:340
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A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.
Authors: Varani Et al.
Arthritis Res Ther 2011;13:R197
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Paraxanthine, the primary metabolite of caffeine, provides protection against DArgic cell death via stimulation of ryanodine receptor channels.
Authors: Guerreiro Et al.
Mol Pharmacol 2008;74:980
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Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.
Authors: Eltzschig Et al.
Blood 2004;104:3986
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