Mouse TSLPR PE-conjugated Antibody Summary
Ala20-Leu233
Accession # BAA92159
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TSLP R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TSLP R PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB5461P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TSLPR
TSLP R, also named Delta (1) and CRLM-2 (2) (cytokine receptor-like module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain. It was subsequently identified to be a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R (3). The TSLP R cDNA encodes a 359 amino acid (aa) residue type 1 membrane protein with a 24 aa residue signal peptide, a 206 aa residue extracellular domain that showed 24% sequence identity with the mouse common gamma receptor, a 23 aa residue transmembrane domain, and a 106 aa residue cytoplasmic domain. The cytoplasmic domain of TSLP R contains a membrane-proximal box1 motif which is known to be important for association with JAKs. An alternatively spliced mRNA variant encoding a soluble TSLP R has also been reported (2). TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction (3, 4).
- Fujio, K. et al. (2000) Blood 95:2204.
- Hiroyama, T. et al. (2000) Biochem. Biophys. Res. Commun. 272:224.
- Park, L.S. et al. (2000) J. Exp. Med. 192:659.
- Pandey, A. et al. (2000) Nat. Immunol. 1:59.
Product Datasheets
Citations for Mouse TSLPR PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease
Authors: Masahiro Yasunaga, Shino Manabe, Yasuhiro Matsumura
Scientific Reports
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JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias
Authors: Sang-Kyu Kim, Deborah A. Knight, Lisa R. Jones, Stephin Vervoort, Ashley P. Ng, John F. Seymour et al.
Genes & Development
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Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation
Authors: H Kabata, AL Flamar, T Mahlakõiv, S Moriyama, HR Rodewald, SF Ziegler, D Artis
Mucosal Immunol, 2020-02-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation
Authors: R Deng, X Chen, Y Zhang, F Bian, N Gao, J Hu, C Wang, RG de Souza, F Lu, SC Pflugfelde, DQ Li
Mucosal Immunol, 2019-07-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9<sup>+</sup> and IL-13<sup>+</sup> type 2 innate lymphoid cell subpopulations.
Authors: Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R
J Allergy Clin Immunol, 2017-11-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells
Authors: A Onodera, M Kiuchi, K Kokubo, M Kato, T Ogino, S Horiuchi, U Kanai, K Hirahara, T Nakayama
J. Immunol., 2017-06-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
Authors: Wiesner, Darin L, Specht, Charles, Lee, Chrono K, Smith, Kyle D, Mukaremera, Liliane, Lee, S Thera, Lee, Chun G, Elias, Jack A, Nielsen, Judith N, Boulware, David R, Bohjanen, Paul R, Jenkins, Marc K, Levitz, Stuart M, Nielsen, Kirsten
PLoS Pathog, 2015-03-12;11(3):e1004701.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Authors: Oh MH, Oh SY, Yu J
J. Immunol., 2011-05-16;186(12):7232-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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