Mouse TLR1 Antibody Summary
Ser25-Asp581
Accession # Q9EPQ1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TLR1
The Toll-like family of molecules are type I transmembrane proteins that serve as pattern recognition receptors for microbial pathogens. There are at least twelve mouse and ten human TLRs that activate the innate immune system following exposure to a variety of microbial species (1, 2). TLRs contain a large number of leucine-rich repeats (LRRs) and a cytoplasmic tail with one Toll/IL-1 receptor (TIR) domain. Mature mouse TLR1 consists of a 557 amino acid (aa) extracellular domain (ECD) with 20 LRRs, a 21 aa transmembrane segment, and a 192 aa cytoplasmic domain (3, 4). Within the ECD, mouse TLR1 shares 60% aa sequence identity with mouse TLR6 and 19%‑27% aa sequence identitity with mouse TLR2, -3, -4, -5, -7, -8, -9, -11, -12, and -13. It shares 73% and 86% aa sequence identity with human and rat TLR1, respectively. TLR1 is expressed on the surface of macrophages, dendritic cells, and tonsillar epithelial cells in ligand-independent association with TLR2 (5‑8). TLR2 additionally associates with TLR6 to form a functional complex with specificity for distinct but related microbial ligands (9‑11). TLR1 and TLR2 cooperate in the recognition of bacterial and protozoal triacylated lipopeptides and glycosylphosphatidylinositols (6, 10‑12). Ligand binding induces TLR1 localization to lipid rafts followed by receptor internalization and activation of NF kappa B (7, 11, 13).
- Miyake, K. (2007) Semin. Immunol. 19:3.
- Hopkins, P.A. and S. Sriskandan (2005) Clin. Exp. Immunol. 140:395.
- SwissProt # Q9EPQ1.
- Matsushima, N. et al. (2007) BMC Genomics 8:124.
- Ochoa, M.-T. et al. (2003) Immunology 108:10.
- Takeuchi, O. et al. (2002) J. Immunol. 169:10.
- Triantafilou, M. et al. (2006) J. Biol. Chem. 281:31002.
- Sandor, F. et al. (2003) J. Cell Biol. 162:1099.
- Nakao, Y. et al. (2005) J. Immunol. 174:1566.
- Ozinsky, A. et al. (2000) Proc. Natl. Acad. Sci. 97:13766.
- Lee, J.Y. et al. (2004) J. Biol. Chem. 279:16971.
- Krishnegowda, G. et al. (2005) J. Biol. Chem. 280:8606.
- Nishiya, T. and A.L. DeFranco (2004) J. Biol. Chem. 279:19008.
Product Datasheets
Citation for Mouse TLR1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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IL-10 Dysregulation Underlies Chemokine Insufficiency, Delayed Macrophage Response, and Impaired Healing in Diabetic Wounds
Authors: Roy R, Zayas J, Mohamed MF et al.
Journal of Investigative Dermatology
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