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Mouse LYVE-1 Antibody

Catalog #: AF2125
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LYVE‑1 in Mouse Liver.
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Citations (134)
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Mouse LYVE-1 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse LYVE-1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse LYVE-1
Ala24-Thr234
Accession # Q8BHC0
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.25 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below
Dual RNAscope ISH-IHC
5-15 µg/mL
Immersion fixed paraffin-embedded sections of mouse liver

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry LYVE‑1 antibody in Mouse Liver by Immunohistochemistry (IHC-Fr). View Larger

LYVE‑1 in Mouse Liver. LYVE-1 was detected in perfusion fixed frozen sections of mouse liver using 15 µg/mL Goat Anti-Mouse LYVE-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of endothelial cells in sinusoids. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Western Blot Detection of Mouse LYVE-1 antibody by Western Blot. View Larger

Detection of Mouse LYVE‑1 by Western Blot. Western blot shows lysates of mouse liver tissue and bEnd.3 mouse brain endothelial cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse LYVE-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for LYVE-1 at approximately 60-65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry/ Immunofluorescence Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence 17D-204 causes viscerotropic abnormalities in the absence of IFN-gamma. H&E sections (a–c) antibody-stained frozen sections (b, d) of spleen (a, b) and liver (c, d) were presented. a Spleen sections from 17D-204-infected animals were indistinguishable at 4 dpi, whereas Angola71-infected animals display loss of white pulp and red pulp architecture and increase in infiltrating macrophages and neutrophils (inset) at 4 dpi. At 11 dpi, 17D-204 infected AGB6 has increased immune infiltration and extramedullary hematopoiesis (inset) but not AB6 mice. b YFV antigen can be detected in the spleen at 4 dpi in both AB6 and AGB6 mice in the red pulp and outer marginal zone area. c 17D-204-infected AB6 mice do not display major histological changes but infected AGB6 mice and Angola71-infected animals had microsteatosis (inset) at 4 dpi. In AGB6 mice, microsteatosis only occurs transiently at 4 dpi and resolved by 11 dpi. Antibody-stained frozen liver sections (d) revealed that YFV antigen could only be detected in infected AGB6 mice at 4 dpi but not AB6 mice, parallel to titer data in Fig. 1g. Original magnification = 40x, n = 4 Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/s41541-017-0039-z), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence Molecular characterization of LECs in the SCS ceiling with RNA FISH.(A-B) Expression of new cLEC/cluster 2 marker genes Ackr3 (A) and Btnl9 (B) by RNA sequencing (left panels) and RNA FISH (right panels). As GFP fluorescence is lost during tissue processing for RNA FISH, immunofluorescence staining for ANXA2 (red) and LYVE1 (green) served as markers for cLECs and fLECs, respectively. Arrows point to cLECs expressing Ackr3 and Btnl9 transcripts (white). ACKR3, atypical chemokine receptor 3; ANXA2, annexin A2; Btnl9, butyrophilin like 9; cLEC, ceiling LEC; FISH, fluorescence in situ hybridization; fLEC, floor-lining LEC; LEC, lymphatic endothelial cell; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1; SCS, subcapsular sinus; UMAP, Uniform Manifold Approximation and Projection. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32251437), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence Molecular characterization of LECs in the SCS ceiling with immunofluorescence staining.(A–C) Expression of new cLEC/cluster 2 marker genes ANXA2 (A), FABP4 (B), and CD36 (C) by RNA sequencing (left panels) and immunofluorescence staining (right panels) in Ackr4-GFP reporter mice. GFP (white) and immunofluorescence costaining for LYVE1 (green) served as markers for cLECs and fLECs, respectively. ACKR4, atypical chemokine receptor 4; ANXA2, annexin A2; CD, cluster of differentiation; cLEC, ceiling LEC; FABP4, fatty acid binding protein 4; fLEC, floor-lining LEC; GFP, green fluorescent protein; LEC, lymphatic endothelial cell; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1; SCS, subcapsular sinus; UMAP, Uniform Manifold Approximation and Projection. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32251437), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence Molecular characterization of LECs in the SCS ceiling with RNA FISH.(A-B) Expression of new cLEC/cluster 2 marker genes Ackr3 (A) and Btnl9 (B) by RNA sequencing (left panels) and RNA FISH (right panels). As GFP fluorescence is lost during tissue processing for RNA FISH, immunofluorescence staining for ANXA2 (red) and LYVE1 (green) served as markers for cLECs and fLECs, respectively. Arrows point to cLECs expressing Ackr3 and Btnl9 transcripts (white). ACKR3, atypical chemokine receptor 3; ANXA2, annexin A2; Btnl9, butyrophilin like 9; cLEC, ceiling LEC; FISH, fluorescence in situ hybridization; fLEC, floor-lining LEC; LEC, lymphatic endothelial cell; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1; SCS, subcapsular sinus; UMAP, Uniform Manifold Approximation and Projection. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32251437), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse LYVE-1 by Immunocytochemistry/Immunofluorescence POSTN is upregulated in (pre)-metastatic LN. Morphometric analysis of POSTN and LYVE1+ lymphatic vessels in experimental (pre)-metastatic LN (in the ear sponge assay using B16F10 cells). CTRLs correspond to mice implanted with a sponge without tumor cells. a–d–g Immunostaining of POSTN (red) and LYVE1 (green) in pre-metastatic (PM) (at 1 week in A, at 2 weeks in d) and in metastatic (M+) LNs (G). Bars = 250 µm. b–e–h Scatter graphs use scatter plots to represent POSTN and LYVE1 densities (in percentage) assessed by a computer assisted method (n ≥ 9). Results are expressed as mean ± SD, and statistical analyses were performed using a Wilcoxon–Mann–Whitney test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). c–f–i Spatial distribution analysis from tissue edge to tissue center. The blue rectangle indicates the area between 0–0.30 mm from the LN border where the cumulate normalized areas of LYVE1 and POSTN were measured and represented in the top right. Maximum distance of migration from the tissue border (Lmax) is indicated. Results are expressed as mean ± SD (Wilcoxon–Mann–Whitney test: *p < 0.05; **p < 0.01). d–i All the results represent the set of two independent experiments Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/35567669), licensed under a CC-BY license. Not internally tested by R&D Systems.

In-situ Hybridization View Larger

Detection of LYVE‑1 in Mouse Liver. Formalin-fixed paraffin-embedded tissue sections of mouse liver were probed for LYVE1 mRNA (ACD RNAScope Probe, catalog # 428451; Fast Red chromogen, ACD catalog # 322360). Adjacent tissue section was processed for immunohistochemistry using goat anti-mouse LYVE1 polyclonal antibody (R&D Systems catalog # AF2125) at 5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-goat IgG VisUCyte HRP Polymer Antibody (Catalog # VC004) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells of sinusoids.

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Preparation and Storage

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Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LYVE-1

Lymphatic vessel endothelial hyaluronan (HA) receptor-1 (LYVE-1) is a recently identified receptor of HA, a linear high molecular weight polymer composed of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. The turnover of HA (several grams/day in humans) occurs primarily in the lymphatics and liver, the two major clearance systems that catabolize approximately 85% and 15% of HA, respectively. LYVE-1 shares 41% homology with the other known HA receptor, CD44. The homology between the two proteins increases to 61% within the HA binding domain. The HA binding domain, known as the link module, is a common structural motif found in other HA binding proteins such as link protein, aggrecan and versican. Human and mouse LYVE-1 share 69% amino acid sequence identity.

LYVE-1 is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels. In addition, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells. LYVE-1 mediates the endocytosis of HA and may transport HA from tissue to lymph by transcytosis, delivering HA to lymphatic capillaries for removal and degradation in the regional lymph nodes. Because of its restricted expression patterns, LYVE-1, along with other lymphatic proteins such as VEGF R3, podoplanin and the homeobox protein propero-related (Prox-1), constitute a set of markers useful for distinguishing between lymphatic and blood microvasculature.

Long Name
Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Entrez Gene IDs
10894 (Human); 114332 (Mouse); 293186 (Rat)
Alternate Names
cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP1; CRSBP-1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; Hyaluronic acid receptor; lymphatic vessel endothelial hyaluronan receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1; LYVE-1; UNQ230/PRO263; XLKD1

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Citations for Mouse LYVE-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

134 Citations: Showing 1 - 10
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  1. Carbon nanotubes exhibit fibrillar pharmacology in primates
    Authors: S Alidori, DLJ Thorek, BJ Beattie, D Ulmert, BA Almeida, S Monette, DA Scheinberg, MR McDevitt
    PLoS ONE, 2017-08-28;12(8):e0183902.
  2. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes
    Authors: Fujimoto N, He Y, D'Addio M et al.
    PLoS Biol.
  3. Liver Sinusoidal Endothelial Cells Contribute to Portal Hypertension Through Collagen Type IV-Driven Sinusoidal Remodeling
    Authors: Gan, C;Yaqoob, U;Lu, J;Xie, M;Anwar, AA;Jalan-Sakrikar, N;Jerez, S;Sehrawat, T;Navarro-Corcuera, A;Kostallari, E;Habash, NW;Cao, S;Shah, VH;
    JCI insight
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  4. Vegfc-expressing cells form heterotopic bone after musculoskeletal injury
    Authors: Vishlaghi, N;Guo, L;Griswold-Wheeler, D;Sun, Y;Booker, C;Crossley, JL;Bancroft, AC;Juan, C;Korlakunta, S;Ramesh, S;Pagani, CA;Xu, L;James, AW;Tower, RJ;Dellinger, M;Levi, B;
    Cell reports
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  5. Spatial Distribution of Non-Immune Cells Expressing Glycoprotein A Repetitions Predominant in Human and Murine Metastatic Lymph Nodes
    Authors: Rouaud, L;Baudin, L;Gautier-Isola, M;Van Meerbeeck, P;Feyereisen, E;Blacher, S;van Baren, N;Kridelka, F;Lucas, S;Noel, A;
    Cancers
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary
    Authors: Anbarci, DN;McKey, J;Levic, DS;Bagnat, M;Capel, B;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Inhibition of TP signaling promotes endometriosis growth and neovascularization
    Authors: Furue, A;Hattori, K;Hosono, K;Tanabe, M;Sato, E;Honda, M;Sekiguchi, K;Ito, Y;Majima, M;Narumiya, S;Kato, K;Amano, H;
    Molecular medicine reports
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels
    Authors: Guo, J;Xu, Z;Gunderson, RC;Xu, B;Michie, SA;
    Biomolecules
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. hESC‐Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine
    Authors: Xiao‐Ling Luo, Yun Jiang, Qiang Li, Xiu‐Jian Yu, Teng Ma, Hao Cao et al.
    Advanced Science
  10. KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis
    Authors: Yoon C, Lu J, Jun Y et al.
    BMC cancer
  11. An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
    Authors: Hansen, SL;Larsen, HL;Pikkupeura, LM;Maciag, G;Guiu, J;Müller, I;Clement, DL;Mueller, C;Johansen, JV;Helin, K;Lerdrup, M;Jensen, KB;
    Science advances
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC
  12. Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern
    Authors: Dietsch, B;Weller, C;Sticht, C;de la Torre, C;Kramer, M;Goerdt, S;G�raud, C;Wohlfeil, SA;
    BMC cancer
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress
    Authors: Junzhuang Chang, Bingqing Guo, Yan Gao, Wei Li, Xiaoyu Tong, Yi Feng et al.
    Research (Wash D C)
  14. Visualization of Organ-Specific Lymphatic Growth: An Efficient Approach to Labeling Molecular Markers in Cleared Tissues
    Authors: C Christ, Z Jakus
    International Journal of Molecular Sciences, 2023-03-07;24(6):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Increased adipose tissue lymphatic vessel density inhibits thermogenesis through elevated neurotensin levels
    Authors: Thien T. Phan, Adri Chakraborty, Madison A. Tatum, Ana Lima-Orellana, Andrea J. Reyna, Joseph M. Rutkowski
    Frontiers in Cell and Developmental Biology
  16. VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
    Authors: J Li, D Huang, B Lei, J Huang, L Yang, M Nie, S Su, Q Zhao, Y Wang
    Elife, 2022-12-09;11(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Three-dimensional characterization of developing and adult ocular vasculature in mice using in toto clearing
    Authors: Marie Darche, Anna Verschueren, Morgane Belle, Leyna Boucherit, Stéphane Fouquet, José Alain Sahel et al.
    Communications Biology
  18. Single and combined impacts of irradiation and surgery on lymphatic vasculature and fibrosis associated to secondary lymphedema
    Authors: F. Buntinx, A. Lebeau, L. Gillot, L. Baudin, R. Ndong Penda, F. Morfoisse et al.
    Frontiers in Pharmacology
  19. The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse
    Authors: Kazuaki Maruyama, Sachiko Miyagawa-Tomita, Yuka Haneda, Mayuko Kida, Fumio Matsuzaki, Kyoko Imanaka-Yoshida et al.
    eLife
  20. Imaging Blood Vessels and Lymphatics in Mouse Trachea Wholemounts
    Authors: Peter Baluk, Donald M. McDonald
    Methods in Molecular Biology
  21. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis
    Authors: Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis et al.
    Frontiers in Immunology
  22. Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
    Authors: A Axelsson R, H Wakimoto, DM DeLaughter, D Reichart, J Gorham, DA Conner, M Lun, CK Probst, N Sakai, RS Knipe, SB Montesi, B Shea, LP Adam, LA Leinwand, W Wan, ES Choi, EL Lindberg, G Patone, M Noseda, N Hübner, CE Seidman, AM Tager, JG Seidman, CY Ho
    Proceedings of the National Academy of Sciences of the United States of America, 2022-07-05;119(28):e2204174119.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. Periostin in lymph node pre-metastatic niches governs lymphatic endothelial cell functions and metastatic colonization
    Authors: Lionel Gillot, Alizée Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durré et al.
    Cellular and Molecular Life Sciences
  24. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development
    Authors: W Xu, NP Nelson-Man, L Bálint, HB Kwon, RB Davis, DCM Dy, JM Dunleavey, B St Croix, KM Caron
    International Journal of Molecular Sciences, 2022-05-20;23(10):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
    Authors: O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis
    Nature Communications, 2022-05-19;13(1):2760.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. Circulating MicroRNA-505 May Serve as a Prognostic Biomarker for Hypertension-Associated Endothelial Dysfunction and Inflammation
    Authors: Qinbo Yang, Peiwei Wang, Yiqing Cai, Yimeng Cui, Jingang Cui, Xiaoye Du et al.
    Frontiers in Cardiovascular Medicine
  27. ADAMTS2 and ADAMTS14 substitute ADAMTS3 in adults for proVEGFC activation and lymphatic homeostasis
    Authors: L Dupont, L Joannes, F Morfoisse, S Blacher, C Monseur, CF Deroanne, A Noël, AC Colige
    JCI Insight, 2022-04-22;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  28. Remodeling lymphatic vessels in intrinsically aged skin on SKH-1 mouse using low dose 5-aminolevulinic acid photodynamic therapy via VEGF-C/VEGFR3 pathway
    Authors: Y Yang, S Shen, Y Cao, D Wang, Z Kang, P Wang, X Wang
    Photodiagnosis and photodynamic therapy, 2022-04-06;0(0):102851.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction
    Authors: Jesus Maria Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng et al.
    Cell Stem Cell
  30. Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics
    Authors: Yan Liang, Kota Kaneko, Bing Xin, Jin Lee, Xin Sun, Kun Zhang et al.
    Developmental Cell
  31. Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment
    Authors: SA Wohlfeil, V Häfele, B Dietsch, C Weller, C Sticht, AS Jauch, M Winkler, CD Schmid, AL Irkens, A Olsavszky, K Schledzews, PS Reiners-Ko, S Goerdt, C Géraud
    Journal of Translational Medicine, 2022-02-02;20(1):62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC/IF
  32. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models
    Authors: RJ Torphy, Y Sun, R Lin, A Caffrey-Ca, Y Fujiwara, F Ho, EN Miller, MD McCarter, TR Lyons, RD Schulick, RM Kedl, Y Zhu
    Nature Communications, 2022-01-10;13(1):97.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
    Authors: J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch
    Nature Communications, 2021-11-29;12(1):6963.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  34. Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
    Authors: C Sogawa-Fuj, Y Fujiwara, A Hanagata, Q Yang, T Mihara, N Kaji, T Kunieda, M Hori
    Bmc Research Notes, 2021-11-27;14(1):438.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  35. Expanded renal lymphatics improve recovery following kidney injury
    Authors: G Baranwal, HA Creed, LM Black, A Auger, AM Quach, R Vegiraju, HE Eckenrode, A Agarwal, JM Rutkowski
    Physiological Reports, 2021-11-01;9(22):e15094.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases
    Authors: Stefaan Verhulst, Elise Anne van Os, Vincent De Smet, Nathalie Eysackers, Inge Mannaerts, Leo A. van Grunsven
    Frontiers in Medicine
  37. Imbalanced Activation of Wnt-/ beta -Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation
    Authors: Philipp-Sebastian Koch, Kajetan Sandorski, Joschka Heil, Christian D. Schmid, Sina W. Kürschner, Johannes Hoffmann et al.
    Frontiers in Physiology
  38. Bone development and fracture healing is normal in mice that have a defect in the development of the lymphatic system
    Authors: Anna L. McCarter, Aysha Khalid, Yating Yi, Marco Monroy, Hu Zhao, Jonathan J. Rios et al.
    Lymphology
  39. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
    Authors: E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer
    PLoS ONE, 2021-09-20;16(9):e0249256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Dual targeting of lymphocyte homing and retention through alpha 4 beta 7 and alpha E beta 7 inhibition in inflammatory bowel disease
    Authors: Bingbing Dai, Jason A. Hackney, Ryan Ichikawa, Allen Nguyen, Justin Elstrott, Luz D. Orozco et al.
    Cell Reports Medicine
  41. KRAS-driven model of Gorham-Stout disease effectively treated with trametinib
    Authors: N Homayun Se, AL McCarter, R Helaers, C Galant, LM Boon, P Brouillard, M Vikkula, MT Dellinger
    JCI Insight, 2021-08-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
    Authors: CC Clement, A D'Alessand, S Thangaswam, S Chalmers, R Furtado, S Spada, G Mondanelli, F Ianni, S Gehrke, M Gargaro, G Manni, LCL Cara, P Runge, WL Tsai, S Karaman, J Arasa, R Fernandez-, A Beck, A Macchiarul, M Gadina, C Halin, F Fallarino, M Skobe, M Veldhoen, S Moretti, S Formenti, S Demaria, RK Soni, R Galarini, R Sardella, G Lauvau, C Putterman, K Alitalo, U Grohmann, L Santambrog
    Nature Communications, 2021-07-21;12(1):4447.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  43. Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
    Authors: D Sz?ke, G Kovács, É Kemecsei, L Bálint, K Szoták-Ajt, P Aradi, A Styevkóné, BL Mui, YK Tam, TD Madden, K Karikó, RP Kataru, MJ Hope, D Weissman, BJ Mehrara, N Pardi, Z Jakus
    Nature Communications, 2021-06-08;12(1):3460.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Single-Cell Transcriptional Heterogeneity of Lymphatic Endothelial Cells in Normal and Inflamed Murine Lymph Nodes
    Authors: E Sibler, Y He, L Ducoli, N Keller, N Fujimoto, LC Dieterich, M Detmar
    Cells, 2021-06-02;10(6):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. Ex Vivo-Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice
    Authors: J Zhu, T Inomata, K Fujimoto, K Uchida, K Fujio, K Nagino, M Miura, N Negishi, Y Okumura, Y Akasaki, K Hirosawa, M Kuwahara, A Eguchi, H Shokirova, A Yanagawa, A Midorikawa, A Murakami
    Investigative Ophthalmology & Visual Science, 2021-06-01;62(7):3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  46. New lymphatic cell formation is associated with damaged brain tissue clearance after penetrating traumatic brain injury
    Authors: FW Meng, JT Yu, JY Chen, PF Yang
    Scientific Reports, 2021-05-13;11(1):10193.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. A cellular and spatial map of the choroid plexus across brain ventricles and ages
    Authors: Neil Dani, Rebecca H. Herbst, Cristin McCabe, Gilad S. Green, Karol Kaiser, Joshua P. Head et al.
    Cell
  48. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance
    Authors: Wanshu Ma, Hyea Jin Gil, Xiaolei Liu, Lauren P. Diebold, Marc A. Morgan, Michael J. Oxendine-Burns et al.
    Science Advances
  49. Mesenchymal stem cells induce tumor stroma formation and epithelial?mesenchymal transition through SPARC expression in colorectal cancer
    Authors: T Naito, R Yuge, Y Kitadai, H Takigawa, Y Higashi, T Kuwai, K Kuraoka, S Tanaka, K Chayama
    Oncology reports, 2021-04-28;45(6):.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  50. Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
    Authors: H Shokirova, T Inomata, T Saitoh, J Zhu, K Fujio, Y Okumura, A Yanagawa, K Fujimoto, J Sung, A Eguchi, M Miura, K Nagino, K Hirosawa, M Kuwahara, Y Akasaki, H Nagase, A Murakami
    Scientific Reports, 2021-04-21;11(1):8647.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A
    Authors: R Luo, Y Cheng, D Chang, T Liu, L Liu, G Pei, N Zhang, Z Wang, K Guo, W Chen, M Li, L Fan, C Zhang, Y Li, W Dai, M Zuo, Y Xu, Y Yao, S Ge, G Xu
    Theranostics, 2021-01-01;11(1):117-131.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  52. Blood and lymphatic systems are segregated by the FLCN tumor suppressor
    Authors: I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota
    Nature Communications, 2020-12-09;11(1):6314.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  53. Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival
    Authors: T Inomata, K Fujimoto, Y Okumura, J Zhu, K Fujio, H Shokirova, M Miura, M Okano, T Funaki, J Sung, N Negishi, A Murakami
    Sci Rep, 2020-11-13;10(1):19817.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  54. Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure
    Authors: M Subileau, N Acar, A Carret, L Bretillon, I Vilgrain, S Bailly, D Vittet
    Sci Rep, 2020-09-29;10(1):16040.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion
    Authors: Ayman M. Ibrahim, Matthew A. Moss, Zane Gray, Michelle D. Rojo, Caitlin M. Burke, Kathryn L. Schwertfeger et al.
    Frontiers in Oncology
  56. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
    Authors: Krivanek J, Soldatov RA, Kastriti ME et al.
    Nature Communications
  57. Defective development and microcirculation of intestine in Npr2 mutant mice
    Authors: C Sogawa-Fuj, A Hanagata, Y Fujiwara, Y Ishida, H Tomiyasu, T Kunieda, H Nakatomi, M Hori
    Sci Rep, 2020-09-08;10(1):14761.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels
    Authors: M Honda, Y Ito, K Hattori, K Hosono, K Sekiguchi, K Tsujikawa, N Unno, M Majima
    J. Cell. Mol. Med., 2020-09-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
    Authors: X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan
    JCI Insight, 2020-07-23;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  60. Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice
    Authors: Ying Wang, Thomas S Chaffee, Rebecca S LaRue, Danielle N Huggins, Patrice M Witschen, Ayman M Ibrahim et al.
    eLife
  61. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D
    Authors: A Chakrabort, CK Scogin, K Rizwan, TS Morley, JM Rutkowski
    Front Physiol, 2020-04-22;11(0):363.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  62. Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation
    Authors: CJ Park, PC Lin, S Zhou, R Barakat, ST Bashir, JM Choi, JA Cacioppo, OR Oakley, DM Duffy, JP Lydon, CJ Ko
    Cell Rep, 2020-04-14;31(2):107496.
    Species: Mouse
    Sample Types: Granulosa Cells
    Applications: IHC
  63. Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1 K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth
    Authors: Kitti Szoták-Ajtay, Dániel Szõke, Gábor Kovács, Judit Andréka, Gábor B. Brenner, Zoltán Giricz et al.
    Frontiers in Bioengineering and Biotechnology
  64. Donor-host Lymphatic Anastomosis After Murine Lung Transplantation
    Authors: Hasina Outtz Outtz Reed, Liqing Wang, Mark L. Kahn, Wayne W. Hancock
    Transplantation
  65. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
    Authors: Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi et al.
    eLife
  66. A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics
    Authors: Lioux G, Liu X, Temi�o S et al.
    Developmental Cell
  67. VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
    Authors: E Song, T Mao, H Dong, LSB Boisserand, S Antila, M Bosenberg, K Alitalo, JL Thomas, A Iwasaki
    Nature, 2020-01-15;577(7792):689-694.
    Species: Mouse
    Sample Types: Tissue
    Applications: IF
  68. Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels
    Authors: László Bálint, Zsombor Ocskay, Bálint András Deák, Petra Aradi, Zoltán Jakus
    Frontiers in Immunology
  69. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease
    Authors: Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe et al.
    eLife
  70. Receptor?interacting serine/threonine?protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer
    Authors: G Zhu, Q Du, X Chen, X Wang, N Tang, F She, Y Chen
    Oncol. Rep., 2019-09-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  71. Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation
    Authors: Shahzad Nawaz Syed, Rebecca Raue, Andreas Weigert, Andreas von Knethen, Bernhard Brüne
    Cells
  72. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth
    Authors: SY Yoon, LC Dieterich, S Karaman, ST Proulx, SB Bachmann, C Sciaroni, M Detmar
    PLoS ONE, 2019-07-25;14(7):e0220341.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  73. Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism
    Authors: KM Lee, GJ Wilson, M Pingen, A Fukuoka, CAH Hansell, R Bartolini, L Medina-Rui, GJ Graham
    PLoS Biol., 2019-05-29;17(5):e3000287.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  74. Imaging Lymphatics in Mouse Lungs
    Authors: Peter Baluk, Donald M. McDonald
    Methods in Molecular Biology
  75. Compartmentalized gut lymph node drainage dictates adaptive immune responses
    Authors: D Esterházy, MCC Canesso, L Mesin, PA Muller, TBR de Castro, A Lockhart, M ElJalby, AMC Faria, D Mucida
    Nature, 2019-04-15;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  76. Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage
    Authors: HO Reed, L Wang, J Sonett, M Chen, J Yang, L Li, P Aradi, Z Jakus, J D'Armiento, WW Hancock, ML Kahn
    J. Clin. Invest., 2019-04-04;129(6):2514-2526.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  77. Brg1 promotes liver regeneration after partial hepatectomy via regulation of cell cycle
    Authors: Baocai Wang, Benedikt Kaufmann, Thomas Engleitner, Miao Lu, Carolin Mogler, Victor Olsavszky et al.
    Scientific Reports
  78. Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly
    Authors: Lara Rodriguez-Laguna, Noelia Agra, Kristina Ibañez, Gloria Oliva-Molina, Gema Gordo, Noor Khurana et al.
    Journal of Experimental Medicine
  79. Lymph/angiogenesis contributes to sex differences in lung cancer through oestrogen receptor alpha signalling
    Authors: Charline Dubois, Natacha Rocks, Silvia Blacher, Irina Primac, Anne Gallez, Melissa García-Caballero et al.
    Endocrine-Related Cancer
  80. Associating liver partition and portal vein ligation for staged hepatectomy: establishment of an animal model with insufficient liver remnant
    Authors: A Dili, V Lebrun, C Bertrand, IA Leclercq
    Lab. Invest., 2019-01-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  81. Identification of ILK as a critical regulator of VEGFR 3 signalling and lymphatic vascular growth
    Authors: Sofia Urner, Lara Planas‐Paz, Laura Sophie Hilger, Carina Henning, Anna Branopolski, Molly Kelly‐Goss et al.
    The EMBO Journal
  82. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation
    Authors: M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet
    Stem Cell Reports, 2018-12-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  83. Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy
    Authors: E Gucciardo, S Loukovaara, P Salven, K Lehti
    Int J Mol Sci, 2018-12-13;19(12):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  84. uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
    Authors: T Durré, F Morfoisse, C Erpicum, M Ebroin, S Blacher, M García-Cab, C Deroanne, T Louis, C Balsat, M Van de Vel, S Kaijalaine, F Kridelka, L Engelholm, I Struman, K Alitalo, N Behrendt, J Paupert, A Noel
    Nat Commun, 2018-12-05;9(1):5178.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  85. Distinct roles of VE ‐cadherin for development and maintenance of specific lymph vessel beds
    Authors: René Hägerling, Esther Hoppe, Cathrin Dierkes, Martin Stehling, Taija Makinen, Stefan Butz et al.
    The EMBO Journal
  86. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice
    Authors: Thomas Leibing, Cyrill Géraud, Iris Augustin, Michael Boutros, Hellmut G. Augustin, Jürgen G. Okun et al.
    Hepatology
  87. Targeted therapy in patients with PIK3CA-related overgrowth syndrome
    Authors: Quitterie Venot, Thomas Blanc, Smail Hadj Rabia, Laureline Berteloot, Sophia Ladraa, Jean-Paul Duong et al.
    Nature
  88. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
    Authors: GD García Nor, CL Ly, DA Cuzzone, RP Kataru, GE Hespe, JS Torrisi, JJ Huang, JC Gardenier, IL Savetsky, MD Nitti, JZ Yu, S Rehal, BJ Mehrara
    Nat Commun, 2018-05-17;9(1):1970.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  89. RIP1 regulates TNF-?-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-?B-VEGF-C pathway
    Authors: CZ Li, XJ Jiang, B Lin, HJ Hong, SY Zhu, L Jiang, XQ Wang, NH Tang, FF She, YL Chen
    Onco Targets Ther, 2018-05-16;11(0):2875-2890.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  90. VEGF-C promotes the development of lymphatics in bone and bone loss
    Authors: D Hominick, A Silva, N Khurana, Y Liu, PC Dechow, JQ Feng, B Pytowski, JM Rutkowski, K Alitalo, MT Dellinger
    Elife, 2018-04-05;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  91. Mir-126 is a conserved modulator of lymphatic development
    Authors: Z Kontarakis, A Rossi, S Ramas, MT Dellinger, DYR Stainier
    Dev. Biol., 2018-03-15;0(0):.
    Species: Mouse
    Sample Types: Embryo
    Applications: Western Blot
  92. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204
    Authors: LKM Lam, AM Watson, KD Ryman, WB Klimstra
    Npj Vaccines, 2018-01-23;3(0):5.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  93. Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response
    Authors: BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br
    Cell Mol Gastroenterol Hepatol, 2017-09-05;5(1):67-82.e1.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  94. Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
    Authors: M García-Cab, J Paupert, S Blacher, M Van de Vel, AR Quesada, MA Medina, A Noël
    J Hematol Oncol, 2017-06-19;10(1):122.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  95. cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-?B pathway
    Authors: X Jiang, C Li, B Lin, H Hong, L Jiang, S Zhu, X Wang, N Tang, X Li, F She, Y Chen
    Cancer Sci., 2017-05-31;108(6):1144-1156.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  96. TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway
    Authors: HaiJie Hong, Lei Jiang, YanFei Lin, CaiLong He, GuangWei Zhu, Qiang Du et al.
    BMC Cancer
  97. Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema
    Authors: Jason C. Gardenier, Geoffrey E. Hespe, Raghu P. Kataru, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. García Nores et al.
    JCI Insight
  98. Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
    Authors: Boksik Cha
    Genes Dev, 2016-06-16;30(12):1454-69.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  99. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD
    J Clin Invest, 2016-05-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  100. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
    J Clin Invest, 2016-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Immunoprecipitation
  101. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation
    Proc Natl Acad Sci USA, 2016-05-02;113(20):E2842-51.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  102. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
    Authors: Sandra D. Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M. Berenjeno, Victoria E.R. Parker, Iñigo Chivite et al.
    Science Translational Medicine
  103. Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines
    Authors: Erin Regan, Robert C. Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D. Minna et al.
    PLOS ONE
  104. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases
    Authors: Jennifer L. Huang, Adrian S. Woolf, Maria Kolatsi-Joannou, Peter Baluk, Richard N. Sandford, Dorien J.M. Peters et al.
    Journal of the American Society of Nephrology
  105. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
    Authors: Zhou Y, Williams J, Smallwood P, Nathans J
    PLoS ONE, 2015-12-02;10(12):e0143650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  106. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
    Authors: Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R
    Dev Biol, 2015-11-02;409(1):218-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  107. Lymph flow regulates collecting lymphatic vessel maturation in vivo.
    Authors: Sweet D, Jimenez J, Chang J, Hess P, Mericko-Ishizuka P, Fu J, Xia L, Davies P, Kahn M
    J Clin Invest, 2015-07-27;125(8):2995-3007.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  108. A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
    Authors: Bianchi R, Teijeira A, Proulx S, Christiansen A, Seidel C, Rulicke T, Makinen T, Hagerling R, Halin C, Detmar M
    PLoS ONE, 2015-04-07;10(4):e0122976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  109. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis
    Authors: Michael J. Flister, Matthew J. Hoffman, Angela Lemke, Sasha Z. Prisco, Nathan Rudemiller, Caitlin C. O’Meara et al.
    Circulation: Cardiovascular Genetics
  110. Machine-based method for multiplex in situ molecular characterization of tissues by immunofluorescence detection
    Authors: Dmitry Yarilin, Ke Xu, Mesruh Turkekul, Ning Fan, Yevgeniy Romin, Sho Fijisawa et al.
    Scientific Reports
  111. Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.
    Authors: Maertens L, Erpicum C, Detry B, Blacher S, Lenoir B, Carnet O, Pequeux C, Cataldo D, Lecomte J, Paupert J, Noel A
    PLoS ONE, 2014-09-15;9(9):e106976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  112. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.
    Authors: D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S
    J Clin Invest, 2014-08-08;124(9):3863-78.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  113. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
    Authors: Kizhatil, Krishnak, Ryan, Margaret, Marchant, Jeffrey, Henrich, Stephen, John, Simon W
    PLoS Biol, 2014-07-22;12(7):e1001912.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  114. Lymphatic function is required prenatally for lung inflation at birth.
    Authors: Jakus Z, Gleghorn J, Enis D, Sen A, Chia S, Liu X, Rawnsley D, Yang Y, Hess P, Zou Z, Yang J, Guttentag S, Nelson C, Kahn M
    J Exp Med, 2014-04-14;211(5):815-26.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  115. Vascular Endothelial Growth Factor Receptor-2 Promotes the Development of the Lymphatic Vasculature
    Authors: Michael T. Dellinger, Stryder M. Meadows, Katherine Wynne, Ondine Cleaver, Rolf A. Brekken
    PLoS ONE
  116. Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes
    Authors: Evan S. Weitman, Seth Z. Aschen, Gina Farias-Eisner, Nicholas Albano, Daniel A. Cuzzone, Swapna Ghanta et al.
    PLoS ONE
  117. Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation
    Authors: Sandrine Levet, Delphine Ciais, Galina Merdzhanova, Christine Mallet, Teresa A. Zimmers, Se-Jin Lee et al.
    Blood
  118. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
    Authors: Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A
    J Biol Chem, 2012-12-05;288(4):2118-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Selection
  119. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
    Authors: Luckashenak N, Wahe A, Breit K, Brakebusch C, Brocker T
    J Immunol, 2012-12-03;190(1):27-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  120. Inducible Tertiary Lymphoid Structures, Autoimmunity, and Exocrine Dysfunction in a Novel Model of Salivary Gland Inflammation in C57BL/6 Mice
    Authors: Michele Bombardieri, Francesca Barone, Davide Lucchesi, Saba Nayar, Wim B. van den Berg, Gordon Proctor et al.
    The Journal of Immunology
  121. Mechanoinduction of lymph vessel expansion
    Authors: Lara Planas-Paz, Boris Strilić, Axel Goedecke, Georg Breier, Reinhard Fässler, Eckhard Lammert
    The EMBO Journal
  122. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.
    Authors: Jeansson M, Gawlik A, Anderson G
    J. Clin. Invest., 2011-05-23;121(6):2278-89.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  123. Sphingosine 1-Phosphate-Induced Motility and Endocytosis of Dendritic Cells Is Regulated by SWAP-70 through RhoA.
    Authors: Ocana-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M, Jessberger R
    J. Immunol., 2011-03-18;186(9):5345-55.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  124. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
    Authors: Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A
    J. Cell Biol., 2010-01-11;188(1):115-30.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  125. ALK1 signaling regulates early postnatal lymphatic vessel development.
    Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
    Blood, 2009-11-10;115(8):1654-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  126. Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth.
    Authors: Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
    Proc. Natl. Acad. Sci. U.S.A., 2009-04-09;106(17):7137-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  127. Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.
    Authors: Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T
    EMBO J., 2009-04-02;28(9):1319-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  128. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.
    Authors: Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A
    J. Immunol., 2008-11-01;181(9):6189-200.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  129. Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice.
    Authors: Zhang J, Dong H, Wang B, Zhu S, Croy BA
    Biol. Reprod., 2008-05-07;79(3):450-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  130. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease.
    Authors: Kowalewska J, Muhlfeld AS, Hudkins KL, Yeh MM, Farr AG, Ravetch JV, Alpers CE
    Am. J. Pathol., 2007-03-01;170(3):981-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  131. Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy.
    Authors: Bagley RG, Weber W, Rouleau C, Teicher BA
    Cancer Res., 2005-11-01;65(21):9741-50.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  132. Angiopoietin-1 is required for Schlemm's canal development in mice and humans
    Authors: BR Thomson, T Souma, SW Tompson, T Onay, K Kizhatil, OM Siggs, L Feng, KN Whisenhunt, TL Yanovitch, L Kalaydjiev, DN Azmanov, S Finzi, CE Tanna, AW Hewitt, DA Mackey, YS Bradfield, E Souzeau, S Javadiyan, JL Wiggs, F Pasutto, X Liu, SW John, JE Craig, J Jin, TL Young, SE Quaggin
    J. Clin. Invest., 2017-11-06;0(0):.
  133. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
    Authors: Bonnardel J, T'Jonck W, Gaublomme D et al..
    Immunity.
  134. Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
    Authors: Guilliams M, Bonnardel J, Haest B Et al.
    Cell

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Mouse LYVE-1 Antibody
By Evan Phillips on 01/08/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Heart tissue Species: Mouse
Immunocytochemistry/Immunofluorescence Mouse LYVE-1 Antibody AF2125
Mouse LYVE-1 Antibody
By Anonymous on 02/02/2017
Application: IHC Sample Tested: Lymph node tissue Species: Mouse

In paraffin embedded sample.
Antigen retrieval with Tris-EDTA Buffer pH 9.0 and fixation with Methanol.
Blocking with TBS 2% BSA -0.5% Triton X-100.
Incubation of Lyve1 (AF2125) at a dilution of 1:400 (O/N at 4C).

Mouse LYVE-1 Antibody
By Anonymous on 09/07/2016
Application: Whole mount immunofluorescence Sample Tested: Whole-mount ear dermis Species: Mouse

Mouse ear dermis was fixed in 2%PFA and blocked/permeabilized overnight in TBS/5% donkey serum/0.5% Tx100 before incubation in AF2125 at a dilution of 1:250 (O/N at 4C). Antibody was then detected using an alexafluor 488 labeled donkey anti goat secondary.

Other Mouse LYVE-1 Antibody AF2125