Home / IL-21 / Mouse IL-21 Antibody

Mouse IL-21 Antibody

Catalog #: AF594
80 Citations 1 Review Datasheet / COA / SDS
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AF594
AF594-SP
IL‑21 in Mouse Splenocytes.
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Citations (80)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse IL-21 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL-21 in ELISAs and Western blots. In sandwich ELISAs, less than 0.5% cross-reactivity with recombinant mouse (rm) IL‑2, rmIL‑4, rmIL-15, and recombinant human IL-21 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant mouse IL‑21 (R&D Systems, Catalog # 594-ML)
Pro25-Ser146
Accession # Q9ES17
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse IL‑21 (Catalog # 594-ML)
Immunocytochemistry
5-15 µg/mL
See below

Mouse IL-21 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
0.2-0.8 µg/mL 

Use in combination with:

Detection Reagent: Mouse IL‑21 Biotinylated Antibody (Catalog # BAF594)

Standard: Recombinant Mouse IL-21 Protein (Catalog # 594-ML)

Neutralization
Measured by its ability to neutralize IL‑21-induced proliferation in the NK-92 human natural killer lymphoma cell line. The Neutralization Dose (ND50) is typically 0.2-2 µg/mL in the presence of 10 ng/mL Recombinant Mouse IL‑21.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry IL‑21 antibody in Mouse Splenocytes by Immunocytochemistry (ICC). View Larger

IL‑21 in Mouse Splenocytes. IL‑21 was detected in immersion fixed concanavalin A-stimulated mouse splenocytes using 15 µg/mL Mouse IL‑21 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF594) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained (green). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Neutralization View Larger

Cell Proliferation Induced by IL-21 and Neutralization by Mouse IL-21 Antibody. Recombinant Mouse IL-21 (Catalog # 594-ML) stimulates proliferation in the NK-92 human natural killer lymphoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-21 (10 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-21 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF594). The ND50 is typically 0.2-2 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-21

Interleukin-21 (IL-21) and its receptor appear to play important roles in the regulation of the immune system. IL-21 is most related to IL-2, IL-4, and IL-15. IL-21 R, also called NILR (novel interleukin receptor), is a type I cytokine receptor with 4 conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta and IL-4 R alpha. Mouse IL-21 is a 146 amino acid (aa) residue protein with a 24 aa signal peptide. Mouse and human IL-21 share 57% amino acid sequence identity. IL‑21 is expressed by activated T cells. Although not fully elucidated, the IL-2 R gamma ( gamma c) chain appears to play a role in IL-21 R signaling. The IL‑21/IL‑21 R interaction appear to play important roles in B and T cell proliferation after antigen stimulation and NK cell maturation.

References
  1. Parrish-Novak, et al. (2000) Nature 408:57.
  2. Ozaki, K. et al. (2000) PNAS 97:11439.
  3. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97:10144.
  4. Asao, H. et al. (2001) J. Immunol. 167:1.
Long Name
Interleukin 21
Entrez Gene IDs
59067 (Human); 60505 (Mouse); 365769 (Rat); 442935 (Canine); 100344172 (Rabbit)
Alternate Names
CVID11; IL21; IL-21; IL-21Za11interleukin-21; interleukin 21; interleukin-21 isoform; Za11

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Citations for Mouse IL-21 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

80 Citations: Showing 1 - 10
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  1. CHD7 variants associated with hearing loss and enlargement of the vestibular aqueduct
    Authors: Roux I, Fenollar-Ferrer C, Lee HJ et al.
    Hum Genet
  2. T. gondii infection induces IL-1R dependent chronic cachexia and perivascular fibrosis in the liver and skeletal muscle.
    Authors: Melchor, S J, Hatter, J A Et al.
    Sci Rep
  3. Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1 alpha : Interplay between O-linked glycosylation and inflammatory cytokines
    Authors: Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics et al.
    Frontiers in Molecular Biosciences
  4. Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids
    Authors: Matsumoto D, Toba H, Kenzaki K et al.
    Regen Ther
  5. Expression of Glial Cell‐Derived Neurotrophic Factor Receptors Within Nucleus Ambiguus During Rat Development
    Authors: Quinton Blount, Ignacio Hernandez‐Morato, Yalda Moayedi, Michael J. Pitman
    The Laryngoscope
  6. Radiation-Induced Senescence in p16+/LUC Mouse Lung Compared to Bone Marrow Multilineage Hematopoietic Progenitor Cells
    Authors: Michael W. Epperly, Donna Shields, Renee Fisher, Wen Hou, Hong Wang, Diala Fatima Hamade et al.
    Radiation Research
  7. Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization
    Authors: Matsunaga M, Kimura M, Ouchi T et al.
    Frontiers in Physiology
  8. Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia
    Authors: Diana Cadena Castaneda, Sonia Jangra, Marina Yurieva, Jan Martinek, Megan Callender, Matthew Coxe et al.
    iScience
  9. Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches
    Authors: Oyler BL, Valencia-Dávila JA, Moysi E et al.
    iScience
  10. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation
    Authors: Freitas-Andrade, M;Comin, CH;Van Dyken, P;Ouellette, J;Raman-Nair, J;Blakeley, N;Liu, QY;Leclerc, S;Pan, Y;Liu, Z;Carrier, M;Thakur, K;Savard, A;Rurak, GM;Tremblay, MÈ;Salmaso, N;da F Costa, L;Coppola, G;Lacoste, B;
    Nature communications
  11. IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells.
    Authors: Ding Y, Li J, Wu Q et al.
    J Immunol
  12. Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties
    Authors: Hellinen L, Pirskanen L, Tengvall-Unadike U et al.
    Pharmaceutics
  13. Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion
    Authors: Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier
    Journal of Experimental Medicine
  14. Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)
    Authors: Jiexiong Xie, Isaura Christiaens, Bo Yang, Wander Van Van Breedam, Tingting Cui, Hans J. Nauwynck
    Journal of General Virology
  15. Expression of MicroRNA miR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus
    Authors: Takasuke Fukuhara, Hiroto Kambara, Mai Shiokawa, Chikako Ono, Hiroshi Katoh, Eiji Morita et al.
    Journal of Virology
  16. Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks
    Authors: Ugur M, Labios RJ, Fenton C et al.
    Immunity
  17. Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis.
    Authors: Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, Vezzalini M, Viviani L, Ricciardi M, Verze G, Assael BM, Melotti P
    PLoS ONE, 2011-07-21;6(7):e22212.
  18. Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1-CD163 and PK15S10-CD163 cells
    Authors: J Xie, I Christiaen, B Yang, I Trus, B Devriendt, T Cui, R Wei, HJ Nauwynck
    Vet. Res., 2018-07-18;49(1):67.
  19. Subset-specific Retention of Donor Myeloid Cells After Major Histocompatibility Complex-matched and Mismatched Liver Transplantation
    Authors: Sarah J. Dart, Amy C. Prosser, Wen Hua Huang, Liu Liu, Andrew D. Lucas, Luc Delriviere et al.
    Transplantation
  20. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation
    Authors: Xuexian O Yang, Huiyuan Zhang, Byung-Seok Kim, Xiaoyin Niu, Juan Peng, Yuhong Chen et al.
    Nature Immunology
  21. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice
    Authors: J Kim, H Okamoto, Z Huang, G Anguiano, S Chen, Q Liu, K Cavino, Y Xin, E Na, R Hamid, J Lee, B Zambrowicz, R Unger, AJ Murphy, Y Xu, GD Yancopoulo, WH Li, J Gromada
    Cell Metab., 2017-06-06;25(6):1348-1361.e8.
  22. Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers
    Authors: Pizzato, HA;Alonso-Guallart, P;Woods, J;Johannesson, B;Connelly, JP;Fehniger, TA;Atkinson, JP;Pruett-Miller, SM;Monsma, FJ;Bhattacharya, D;
    bioRxiv : the preprint server for biology
  23. Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response
    Authors: C Wang, B Ming, X Wu, T Wu, S Cai, P Hu, J Tang, Z Tan, C Liu, J Zhong, F Zheng, L Dong
    EBioMedicine, 2019-06-28;0(0):.
  24. Antibody-based delivery of cytokine payloads to carbonic anhydrase IX leads to cancer cures in immunocompetent tumor-bearing mice
    Authors: B Ziffels, M Stringhini, P Probst, T Fugmann, T Sturm, D Neri
    Mol. Cancer Ther., 2019-06-18;0(0):.
  25. TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cell on Hair Follicle Regeneration
    Authors: Zhang C, Li Y, Qin J et al.
    Frontiers in Pharmacology
  26. Glioma progression is shaped by genetic evolution and microenvironment interactions
    Authors: Varn FS, Johnson KC, Martinek J Et al.
    Cell
  27. Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH
    Authors: Sabine Daemen, Mandy M. Chan, Joel D. Schilling
    STAR Protocols
  28. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury
    Authors: K Vaibhav, M Braun, K Alverson, H Khodadadi, A Kutiyanawa, A Ward, C Banerjee, T Sparks, A Malik, MH Rashid, MB Khan, MF Waters, DC Hess, AS Arbab, JR Vender, N Hoda, B Baban, KM Dhandapani
    Sci Adv, 2020-05-29;6(22):eaax8847.
  29. Differential Effect of Non-Thermal Plasma RONS on Two Human Leukemic Cell Populations
    Authors: Hager Mohamed, Eric Gebski, Rufranshell Reyes, Samuel Beane, Brian Wigdahl, Fred C. Krebs et al.
    Cancers (Basel)
  30. Novel Permissive Cell Lines for Complete Propagation of Hepatitis C Virus
    Authors: Mai Shiokawa, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Toru Okamoto, Noriyuki Watanabe et al.
    Journal of Virology
  31. GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma
    Authors: Williams P, Braine C, Foxworth N et al.
    J Neuroinflammation
  32. Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket
    Authors: EN Schmidt, D Lamprinaki, KA McCord, M Joe, M Sojitra, A Waldow, J Nguyen, J Monyror, EN Kitova, F Mozaneh, XY Guo, J Jung, JR Enterina, GC Daskhan, L Han, AR Krysler, CR Cromwell, BP Hubbard, LJ West, M Kulka, S Sipione, JS Klassen, R Derda, TL Lowary, LK Mahal, MR Riddell, MS Macauley
    Nature Communications, 2023-04-22;14(1):2327.
  33. Cellular and Mucosal Immune Responses Following Vaccination with Inactivated Mutant of Escherichia coli O157:H7
    Authors: Schaut, RG;Boggiatto, PM;Loving, CL;Sharma, VK;
    Sci Rep
  34. Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors
    Authors: Lise Lefèvre, Jason S. Iacovoni, Hélène Martini, Julie Bellière, Damien Maggiorani, Marianne Dutaur et al.
    Cellular and Molecular Life Sciences
  35. Dysregulated Generation of Follicular Helper T Cells in the Spleen Triggers Fatal Autoimmune Hepatitis in Mice
    Authors: Nobuhiro Aoki, Masahiro Kido, Satoru Iwamoto, Hisayo Nishiura, Ryutaro Maruoka, Junya Tanaka et al.
    Gastroenterology
  36. Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing
    Authors: Li H, Bräunig S, Dhapolar P et al.
    eLife
  37. Tolerogenic IDO1+CD83- Langerhans Cells in Sentinel Lymph Nodes of Patients with Melanoma
    Authors: G Gerlini, P Di Gennaro, N Pimpinelli, S Sestini, L Borgognoni
    International Journal of Molecular Sciences, 2022-03-22;23(7):.
  38. Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
    Authors: M Wagner, M Yoshihara, I Douagi, A Damdimopou, S Panula, S Petropoulo, H Lu, K Pettersson, K Palm, S Katayama, O Hovatta, J Kere, F Lanner, P Damdimopou
    Nat Commun, 2020-03-02;11(1):1147.
  39. Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa.
    Authors: Thomi R, Yerly D, Yawalkar N et al.
    Br. J. Dermatol.
  40. Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy
    Authors: Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu et al.
    Journal of Virology
  41. High Mobility Group A2 protects cancer cells against telomere dysfunction
    Authors: Suchitra Natarajan, Farhana Begum, Jeonga Gim, Landon Wark, Dana Henderson, James R. Davie et al.
    Oncotarget
  42. An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells
    Authors: Mart M Lamers, Jelte van der Vaart, Kèvin Knoops, Samra Riesebosch, Tim I Breugem, Anna Z Mykytyn et al.
    The EMBO Journal
  43. Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease
    Authors: Akgul, A;Freguia, CF;Maddaloni, M;Hoffman, C;Voigt, A;Nguyen, CQ;Fanger, NA;Fanger, GR;Pascual, DW;
    Scientific reports
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  44. Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids
    Authors: Matsumoto D, Toba H, Kenzaki K et al.
    Regen Ther
  45. CHD7 variants associated with hearing loss and enlargement of the vestibular aqueduct
    Authors: Roux I, Fenollar-Ferrer C, Lee HJ et al.
    Hum Genet
  46. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation
    Authors: Freitas-Andrade, M;Comin, CH;Van Dyken, P;Ouellette, J;Raman-Nair, J;Blakeley, N;Liu, QY;Leclerc, S;Pan, Y;Liu, Z;Carrier, M;Thakur, K;Savard, A;Rurak, GM;Tremblay, MÈ;Salmaso, N;da F Costa, L;Coppola, G;Lacoste, B;
    Nature communications
  47. Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket
    Authors: EN Schmidt, D Lamprinaki, KA McCord, M Joe, M Sojitra, A Waldow, J Nguyen, J Monyror, EN Kitova, F Mozaneh, XY Guo, J Jung, JR Enterina, GC Daskhan, L Han, AR Krysler, CR Cromwell, BP Hubbard, LJ West, M Kulka, S Sipione, JS Klassen, R Derda, TL Lowary, LK Mahal, MR Riddell, MS Macauley
    Nature Communications, 2023-04-22;14(1):2327.
  48. Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4-pRB Axis in Fibroblasts at the Invasive Tumor Edge
    Authors: Bouchard G, Garcia-Marques FJ, Karacosta LG et al.
    Cancer Research
  49. Monocyte Gene and Molecular Expression Profiles Suggest Distinct Effector and Regulatory Functions in Beninese HIV Highly Exposed Seronegative Female Commercial Sex Workers
    Authors: L Blondin-La, L Fourcade, A Modica, M Aranguren, N de Montign, AC Labbé, M Alary, F Guédou, J Poudrier, M Roger
    Viruses, 2022-02-10;14(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  50. Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization
    Authors: Matsunaga M, Kimura M, Ouchi T et al.
    Frontiers in Physiology
  51. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection
    Authors: Z Shen, J Wu, Z Gao, J Wang, H Zhu, R Mao, X Wang, J Zhang, Y Xie, J Liu
    Theranostics, 2020-04-25;10(12):5600-5612.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  52. Regulation of Transcription Factor E2-2 in Human Plasmacytoid Dendritic Cells by Monocyte-Derived TNF&alpha
    Authors: HK Dewald, HJ Hurley, P Fitzgerald
    Viruses, 2020-01-31;12(2):.
    Species: Human
    Sample Types: Whole Blood
    Applications: Flow Cytometry
  53. Chronic myelogenous leukemia stem cells require cell-autonomous pleiotrophin signaling
    Authors: HA Himburg, M Roos, T Fang, Y Zhang, CM Termini, L Schlussel, MM Kim, A Pang, J Kan, L Zhao, H Suh, JP Sasine, G Sapparapu, PM Bowers, G Schiller, JP Chute
    J. Clin. Invest., 2020-01-02;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  54. Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf
    Authors: KM Hooper, W Kong, D Ganea
    PLoS ONE, 2017-06-12;12(6):e0179184.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  55. Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1(+)CXCR5(-/dim) B-helper T cell induction
    Authors: T Eri, K Kawahata, T Kanzaki, M Imamura, K Michishita, L Akahira, E Bannai, N Yoshikawa, Y Kimura, T Satoh, S Uematsu, H Tanaka, K Yamamoto
    Sci Rep, 2017-04-26;7(0):46037.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  56. Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
    Authors: Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, Azimi N, Tagaya Y
    J Biol Chem, 2015-07-16;290(37):22338-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  57. STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.
    Authors: Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh SL, Goswami R, Pham D, Levy DE, Brutkiewicz RR, Blum JS, Cooper S, Hangoc G, Broxmeyer HE
    Blood, 2011-04-19;117(23):6198-201.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  58. Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
    Authors: McGuire HM, Walters S, Vogelzang A
    Diabetes, 2011-03-01;60(3):867-75.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  59. IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
    Authors: Rynda A, Maddaloni M, Ochoa-Reparaz J, Callis G, Pascual DW
    PLoS ONE, 2010-01-14;5(1):e8720.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  60. Cytokine-secreting follicular T cells shape the antibody repertoire.
    Authors: Reinhardt RL, Liang HE, Locksley RM
    Nat. Immunol., 2009-03-01;10(4):385-93.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ELISpot Development
  61. Tumor-specific Th17-polarized cells eradicate large established melanoma.
    Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
    Blood, 2008-03-19;112(2):362-73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  62. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
    Authors: Wei L, Laurence A, Elias KM, O'Shea JJ
    J. Biol. Chem., 2007-09-20;282(48):34605-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  63. Expression and one-step purification of bovine interleukin-21 (IL-21) in silkworms using a hybrid baculovirus expression system.
    Authors: Muneta Y, Nagaya H, Minagawa Y, Enomoto C, Matsumoto S, Mori Y
    Biotechnol. Lett., 2004-09-01;26(18):1453-8.
    Species: Bovine
    Sample Types: Recombinant Protein
    Applications: Western Blot
  64. IL-21 induces the functional maturation of murine NK cells.
    Authors: Brady J, Hayakawa Y, Smyth MJ, Nutt SL
    J. Immunol., 2004-02-15;172(4):2048-58.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  65. IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice.
    Authors: Di Carlo E, Comes A, Orengo AM, Rosso O, Meazza R, Musiani P, Colombo MP, Ferrini S
    J. Immunol., 2004-02-01;172(3):1540-7.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  66. Preclinical Efficacy of a PARP-1 Targeted Auger-Emitting Radionuclide in Prostate Cancer
    Authors: Sreekumar S, Zhou D, Mpoy C et al.
    International journal of molecular sciences
  67. Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency
    Authors: ES Kim, BH Yoon, SM Lee, M Choi, EH Kim, BW Lee, SY Kim, CG Pack, YH Sung, IJ Baek, CH Jung, TB Kim, JY Jeong, CH Ha
    Experimental & Molecular Medicine, 2022-02-03;0(0):.
  68. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD
    Authors: JP Gleeson, HQ Estrada, M Yamashita, CN Svendsen, SR Targan, RJ Barrett
    Int J Mol Sci, 2020-02-20;21(4):.
  69. Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4-pRB Axis in Fibroblasts at the Invasive Tumor Edge
    Authors: Bouchard G, Garcia-Marques FJ, Karacosta LG et al.
    Cancer Research
  70. Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonization
    Authors: Mir RA, Schaut RG, Allen HK, et al.
    PLoS ONE
  71. Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow.
    Authors: Gakhar, Gunjan, Navarro, Vicente, Jurish, Madelyn, Lee, Guang Yu, Tagawa, Scott T, Akhtar, Naveed H, Seandel, Marco, Geng, Yue, Liu, He, Bander, Neil H, Giannakakou, Paraskev, Christos, Paul J, King, Michael, Nanus, David M
    PLoS ONE, 2013-12-27;8(12):e85143.
  72. Amphipathic alpha-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.
    Authors: Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y
    PLoS Pathog, 2014-12-11;10(12):e1004534.
  73. Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer
    Authors: Sophia M. Orbach, Michael D. Brooks, Yining Zhang, Scott E. Campit, Grace G. Bushnell, Joseph T. Decker et al.
    Clinical & Experimental Metastasis
  74. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients
    Authors: Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma DJ van de Berg, Paul J Lucassen, Anne-Marie van Dam
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Mouse IL-21 Antibody
By Katie Myers on 11/14/2022
Application: ELISA Sample Tested: Serum Species: Mouse

Worked well as a capture spot for our Mouse Elisa.

ELISA Mouse IL-21 Antibody AF594