Mouse IL-17RB APC-conjugated Antibody Summary
Arg18-Gly286
Accession # Q9JIP3
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IL‑17 RB in CHO Chinese Hamster Cell Line Transfected with Mouse IL-17 RB by Flow Cytometry. CHO Chinese hamster ovary cell line transfected with mouse IL-17 RB was stained with Rat Anti-Mouse IL-17 RB APC-conjugated Monoclonal Antibody (Catalog # FAB10402A, filled histogram) or isotype control antibody (Catalog # IC005A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-17RB
The Interleukin 17 (IL-17) family of cytokines, comprising six members (IL-17, IL-17B through IL-17F), are structurally related proteins with a conserved cysteine-knot structure. These proinflammatory cytokines can induce local cytokine production and are involved in the regulation of the immune response. The cognate receptors activated by some of these cytokines have been identified (1, 2). Interleukin-17B Receptor (IL-17 RB), also known as IL-17 Rh1, IL-17E R and EVI27, represents the second receptor of the IL-17 family cytokines to be recognized (2‑4). Mouse IL-17 RB cDNA encodes a 499 amino acid (aa) type I membrane protein with a putative 17 aa signal peptide, a 269 aa extracellular domain, a 21 aa transmembrane domain and a 192 aa cytoplasmic tail. As a result of alternative splicing, a secreted variant of IL-17 RB also exists (5). Human and mouse IL‑17 RB share 76% aa sequence identity. IL-17 RB is approximately 20% identical to the human and mouse IL‑17 R. However, the receptors share many conserved cysteine residues within their extracellular domains as well as additional conserved elements within their cytoplasmic domains. At least three additional type I transmembrane receptors with homology to IL‑17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have been reported (2, 6). By Northern blot analysis, mouse IL-17 RB is highly expressed in liver and testes and is expressed at lower levels in kidney and lung. It is also expressed in some hematopoietic cell lines, including selected T cell, B cell, and myeloid cell lines (2‑4). The expression of IL-17 RB is significantly upregulated under inflammatory conditions (7). IL-17 RB binds strongly to IL-17E and weakly to IL-17B. It does not bind IL-17 or IL-17F. Activation of IL-17 RB by its ligands results in the activation of nuclear factor kappa-B (2‑4).
- Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
- Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155.
- Shi, Y. et al. (2000) J. Biol. Chem. 275:19167.
- Lee, J. et al. (2001) J. Biol. Chem. 276:1660.
- Tian, E. et al. (2000) Oncogene 19:2098.
- Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
- Hurst, S.D. et al. (2002) J. Immunol. 169:443.
Product Datasheets
Citations for Mouse IL-17RB APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner
Authors: Zhang, Y;Zhang, W;Zhao, J;Ito, T;Jin, J;Aparicio, AO;Zhou, J;Guichard, V;Fang, Y;Que, J;Urban, JF;Hanna, JH;Ghosh, S;Wu, X;Ding, L;Basu, U;Huang, Y;
Nature immunology
Applications: Flow Cytometry -
ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
Authors: PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson
BMC Immunol., 2019-12-10;20(1):47.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin 25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice
Authors: P Mantani, P Dunér, E Bengtsson, I Ljungcrant, L Sundius, F To, J Nilsson, H Björkbacka, GN Fredrikson
J. Biol. Chem., 2018-03-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor
Authors: Q Li, D Li, X Zhang, Q Wan, W Zhang, M Zheng, L Zou, C Elly, JH Lee, YC Liu
Immunity, 2018-02-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9<sup>+</sup> and IL-13<sup>+</sup> type 2 innate lymphoid cell subpopulations.
Authors: Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R
J Allergy Clin Immunol, 2017-11-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
Authors: Hams, Emily, Locksley, Richard, McKenzie, Andrew N, Fallon, Padraic
J Immunol, 2013-10-28;191(11):5349-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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