Mouse IL-15R alpha (NP_032384) VersaClone cDNA

Mouse IL-15R alpha (NP_032384) VersaClone cDNA Summary

Specifications

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Background: IL-15R alpha

IL-15 Ra (Interleukin 15 Receptor alpha), also known as CD215, is a transmembrane glycoprotein that plays an important role in NK and CD8+ memory T cell homeostasis and activation. It transmits IL-15 induced signals and additionally interacts with a complex of IL-2 R beta and the common gamma chain (gammaC) which are also subunits of the IL-2 receptor complex. In transpresentation, IL-15/IL-15 Ra complexes are expressed on the surface of one cell and interact with complexes of IL-2 R beta/gammaC on adjacent cells. IL-15/IL-15 Ra complexes can transmit reverse signaling that promotes adhesion and activation of the IL-15/IL-15 Ra expressing cells. Shed soluble forms of IL-15 Ra retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity.

Related Research Areas

• Common gamma Chain Receptor Family
• Cytokine and Growth Factor Receptors on VSMC
• Group 1 ILCs
• Isolation, Culture, and Identification of Natural Killer Cells
• Natural Killer T (NKT) Cells
• Receptors in the Jak/STAT Pathway