Home / Myosin Light Chain Kinase Inhibitors / ML 7 hydrochloride

ML 7 hydrochloride

Catalog #: 4310
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4310/10
4310/50
ML 7 hydrochloride | CAS No. 110448-33-4 | Myosin Light Chain Kinase Inhibitors
1 Image
Description: Selective inhibitor of myosin light chain kinase

Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

Purity: ≥98%

Product Details
Citations (11)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

Technical Data

M.Wt:
452.74
Formula:
C15H17IN2O2S.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
110448-33-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
    Martinelli, Roberta, Kamei, Masataka, Sage, Peter T, Massol, Ramiro, Varghese, Laya, Sciuto, Tracey, Toporsian, Mourad, Dvorak, Ann M, Kirchhausen, Tomas, Springer, Timothy, Carman, Christop
    J Cell Biol, 2013;201(3):449-65.
  2. Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
    Saitoh et al.
    J.Biol.Chem., 1987;262:7796
  3. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.
    Meinders et al.
    Blood, 2015;125:1957

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for ML 7 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 7 hydrochloride include:

11 Citations: Showing 1 - 10

  1. Synaptopodin stress fiber and contractomere at the epithelial junction.
    Authors: William M Et al.
    J Cell Biol  2022;221
  2. Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development.
    Authors: Clifford J Et al.
    Cell  2019;179:90-105.e21
  3. Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments.
    Authors: Lee Et al.
    Nat Commun  2019;10:529
  4. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
    Authors: Tharp Et al.
    Cell Metab  2018;27:602
  5. Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
    Authors: Nicoletta Et al.
    Cell  2018;172:1063-1078.e19
  6. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun  2017;8:14348
  7. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon.
    Authors: Ets
    Front Pharmacol  2016;7:516
  8. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    J Neurosci  2015;6:6364
  9. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Authors: Leoni Et al.
    J Clin Invest  2015;125:1215
  10. Eph-Ephrin signaling and focal adhesion kinase regulate actomyosin-dependent apical constriction of ciliary band cells.
    Authors: Robert D Et al.
    Development  2014;141:1075-84
  11. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    Am J Physiol Renal Physiol  2013;33:11206

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ML 7 hydrochloride

There are currently no reviews for this product. Be the first to review ML 7 hydrochloride and earn rewards!

Have you used ML 7 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.