Misoprostol
Chemical Name: (±)-(11a,13E)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid methyl ester
Purity: ≥99%
Biological Activity
Misoprostol is a cytoprotective prostaglandin E1 analog that displays agonist activity at EP receptors. Ki values are 120, 250, 67 and 67 nM at cloned mouse EP1, EP2, EP3 and EP4 receptors respectively. Prevents NSAID-induced gastric ulceration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial.
Graham et al.
Lancet, 1988;2:1277 -
Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.
Smith et al.
J.Pharmacol.Exp.Ther., 1994;271:390 -
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Kiriyama et al.
Br.J.Pharmacol., 1997;122:217
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