Miro1 Reducer
Chemical Name: N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Purity: ≥98%
Biological Activity
Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models.
Hsieh et al.
Cell Metab., 2019;30:1131
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Citation for Miro1 Reducer
The citations listed below are publications that use Tocris products. Selected citations for Miro1 Reducer include:
1 Citation: Showing 1 - 1
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A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.
Authors: Manfred Et al.
Cancer Res 2022;82:3701-3717
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