MIRA-1
Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Biological Activity
MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
Bykov et al.
J.Biol.Chem., 2005;280:30384 -
Strategies for therapeutic targeting of the p53 pathway in cancer.
Wiman
Cell Death Differ., 2006;13:921 -
p53 in breast cancer: mutation and countermeasures.
Kumar et al.
Front.Biosci., 2007;12:4168
Product Datasheets
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Citation for MIRA-1
The citations listed below are publications that use Tocris products. Selected citations for MIRA-1 include:
1 Citation: Showing 1 - 1
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Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents.
Authors: Saha Et al.
Br J Cancer 2014;110:2224
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