Mexiletine hydrochloride

Catalog #: 2596
2 Citations Datasheet / COA / SDS

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2596/50

Mexiletine hydrochloride | CAS No. 5370-01-4 | Voltage-gated Sodium Channel Blockers

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Description: Na+ channel blocker; antiarrhythmic agent

Alternative Names: Ko 1173

Chemical Name: 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride

Purity: ≥99%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC₅₀ values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Technical Data

M.Wt:

215.72

Formula:

C₁₁H₁₇NO.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

5370-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Optically active mexil. analogues as stereoselective blockers of voltage-gated Na⁺ channels.
Franchini et al.
J.Med.Chem., 2003;46:5238
Neuroprotective effect of mexil. in the central nervous system of diabetic rats.
Ates et al.
Mol.Cell.Biochem., 2006;286:125
Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents.
Bellis et al.
Br.J.Pharmacol., 2006;149:300

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Mexiletine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:

2 Citations: Showing 1 - 2

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling.
Authors: Rojas Et al.
Front Cell Neurosci 2015;9:203
Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress.
Authors: Rojas Et al.
Front Cell Neurosci 2014;8:24

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