Mesopram
Chemical Name: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone
Purity: ≥98%
Biological Activity
Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents.
Dinter et al.
J.Neuroimmunol., 2000;108:136 -
The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice.
Loher et al.
J.Pharmacol.Exp.Ther., 2003;305:549 -
Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats.
McKenna et al.
Endocrinology, 2005;146:208
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