Home / Melanocortin Receptor Agonists / Melanotan II

Melanotan II

Catalog #: 2566
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2566/1
Melanotan II
1 Image
Description: High affinity melanocortin receptor agonist
Alternative Names: MT-II

Purity: ≥95%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Melanotan II is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Technical Data

M.Wt:
1024.19
Formula:
C50H69N15O9
Sequence:
XDHFRWK

(Modifications: X = Nle & N-terminal Ac, Asp-2 = β-Asp, Phe-4 = D-Phe, Lys-7 = ε-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide)

Solubility:
Soluble to 0.70 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
121062-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula.
    Martin et al.
    Eur.J.Pharmacol., 2002;454:71
  2. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.
    Ter Laak et al.
    Eur.J.Pharmacol., 2003;462:179
  3. Melanocortin receptors: perspectives for novel drugs.
    Wikber
    Eur.J.Pharmacol., 1999;375:295
  4. Melanocortin receptors: perspectives for novel drugs.
    Wikber
    Eur.J.Pharmacol., 1999;375:395

Product Datasheets

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Citation for Melanotan II

The citations listed below are publications that use Tocris products. Selected citations for Melanotan II include:

1 Citation: Showing 1 - 1

  1. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
    Authors: Nøhr Et al.
    Neurochem Int  2017;102:105

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