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Megestrol Acetate

Catalog #: 6285 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6285/50
Megestrol Acetate | CAS No. 595-33-5 | Progesterone Receptor Agonists
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Description: Synthetic progesterone analog

Chemical Name: 17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione

Purity: ≥98%

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Biological Activity

Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

Technical Data

M.Wt:
384.51
Formula:
C24H32O4
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
595-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Megestrol acetate in cancer anorexia and weight loss.
    Tchekmedyian et al.
    Cancer., 1992;69:1268
  2. The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo.
    Zhang and Chow
    Clin.Cancer.Res., 2004;10:5226

Product Datasheets

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⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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