Mefloquine hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Early antischistosomal leads identified from in vitro and in vivo screening of the Medicines for Malaria Venture Pathogen Box.
   Pasche et al.
   ACS Infect.Dis., 2019;5:102
2. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
   Wong et al.
   Nat.Microbiol., 2017;2:17031
3. Antimalarials. 7. Bis(trifluoromethyl)-α-(2-piperidyl)-4-quinolinemethanols.
   Ohnmacht et al.
   J.Med.Chem., 1971;14:926
4. Potent block of Cx36 and Cx50 gap junction channels by meflo.
   Cruikshank et al.
   Proc.Natl.Acad.Sci.U.S.A., 2004;101:12364
5. Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs.
   Jeon et al.
   Antimicrob.Agents Chemother., 2020;

Product Datasheets