MDL 72222

Catalog #: 0640
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0640/50

MDL 72222 | CAS No. 40796-97-2 | 5-HT3 Receptor Antagonists

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Description: 5-HT3 antagonist

Chemical Name: Tropanyl 3,5-dichlorobenzoate

Purity: ≥99%

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Product Details

Citations (6)

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Biological Activity

MDL 72222 is a 5-HT₃ antagonist.

Technical Data

M.Wt:

314.21

Formula:

C₁₅H₁₇Cl₂NO₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

40796-97-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).
Jinka T, Rasley B, Drew K
J Neurochem, 2012;122(5):934-40.
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.
Fozard
Naunyn Schmiedebergs Arch.Pharmacol., 1984;326:36
The pharmacology and function of 5-HT₃ receptors.
Richardson and Engel
Trends Neurosci., 1986;9:424

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Citations for MDL 72222

The citations listed below are publications that use Tocris products. Selected citations for MDL 72222 include:

6 Citations: Showing 1 - 6

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
Neuropsychopharmacology 2015;40:3015
Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).
Authors: Jinka Et al.
J Neurochem 2012;122:934
Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Neuron 2007;54:599
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327

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