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MD13

Catalog #: 7503 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7503/5
MD13 | Active Degraders
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Description: Potent MIF Degrader (PROTAC®)

Chemical Name: 8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-(4-(7-hydroxy-2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)octanamide

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

MD13 is a potent MIF (macrophage migration inhibitory factor) Degrader (PROTAC®) (DC50 < 100 nM; Dmax = 92% after 6 h). MD13 comprises the cereblon ligand Pomalidomide (Cat. No. 6302) joined by a linker to a MIF inhibitor. MD13 reduces MIF levels, arrests cells at the G2/M phase and inhibits proliferation of A549 lung carcinoma cells. Growth of A549 cell 3D spheroids is also inhibited by MD 13.

Negative control MD15 (Cat.No. 7504) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
653.69
Formula:
C35H35N5O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with kind permission of Professor Dekker.

Product Datasheets

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Reconstitution Calculator

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