Mca-PLAQAV-Dpa-RSSSR-NH2 Fluorogenic Peptide Substrate
Mca-PLAQAV-Dpa-RSSSR-NH2 Fluorogenic Peptide Substrate Summary
Product Specifications
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2
Mca: (7-Methoxycoumarin-4-yl) acetyl, Dpa: N-3-(2, 4-Dinitrophenyl)-L-2,3-diaminopropionyl.
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
ES003
Formulation | Supplied as a stock solution in dimethyl sulfoxide (DMSO) at a concentration of 8.0 mg/mL or 4 mM. |
Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light. |
Reconstitution Calculator
Citations for Mca-PLAQAV-Dpa-RSSSR-NH2 Fluorogenic Peptide Substrate
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Porcine reproductive and respiratory syndrome virus infection activates ADAM17 to induce inflammatory responses
Authors: Liu, J;Su, G;Duan, C;Sun, Z;Xiao, S;Zhou, Y;Fang, L;
Veterinary microbiology
Species: Primate - Cercopithecus Aethiops
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1 release requires Nef-induced caspase activation
Authors: J Segura, J Ireland, Z Zou, G Roth, J Buchwald, TJ Shen, E Fischer, S Moir, TW Chun, PD Sun
PLoS ONE, 2023-02-13;18(2):e0281087.
Species: Human
Sample Types: Peptide
Applications: Bioassay -
Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition
Authors: N Zhukovsky, M Silvano, T Filloux, S Gonzalez, KH Krause
International Journal of Molecular Sciences, 2022-07-03;23(13):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
Authors: L Scherschin, M Prem, I Kremenetsk, I Tinhofer, P Vajkoczy, AG Karbe, JS Onken
International Journal of Molecular Sciences, 2022-01-17;23(2):.
Species: Human
Sample Types: Cell Lysates
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Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells
Authors: N Saha, K Xu, Z Zhu, D Robev, T Kalidindi, Y Xu, J Himanen, E de Stanchi, NVK Pillarsett, DS Dimitrov, DB Nikolov
Translational Oncology, 2021-11-09;15(1):101265.
Species: Human
Sample Types: Peptide
Applications: Bioassay -
Oncogenic KRAS promotes growth of lung cancer cells expressing SLC3A2-NRG1 fusion via ADAM17-mediated shedding of NRG1
Authors: DH Shin, SH Kim, M Choi, YK Bae, C Han, BK Choi, SS Kim, JY Han
Oncogene, 2021-11-06;0(0):.
Species: Human
Sample Types: Recombinant Proteins
Applications: Bioassay -
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1alpha-ADAM17 pathway?
Authors: G Lian, X Li, L Zhang, Y Zhang, L Sun, X Zhang, H Liu, Y Pang, W Kong, T Zhang, X Wang, C Jiang
EBioMedicine, 2019-10-19;0(0):.
Species: Mouse
Sample Types: Protein
Applications: Bioassay -
Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation
Authors: Y Ye, J Toczek, K Gona, HY Kim, J Han, M Razavian, R Golestani, J Zhang, TL Wu, M Ghosh, JJ Jung, MM Sadeghi
Sci Rep, 2018-08-03;8(1):11647.
Species: Human
Sample Types: Recombinant Protein
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Tumor necrosis factor ?-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells
Authors: EH Bae, IJ Kim, HS Choi, HY Kim, CS Kim, SK Ma, IS Kim, SW Kim
Korean J. Physiol. Pharmacol., 2018-02-23;22(2):135-143.
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Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-? converting enzyme
Authors: JB Schaal, T Maretzky, DQ Tran, PA Tran, P Tongaonkar, CP Blobel, AJ Ouellette, ME Selsted
J. Biol. Chem., 2018-01-09;0(0):.
Applications: Bioassay -
Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis
Authors: I González-F, P Santulli, S Chouzenoux, F Carmona, C Chapron, F Batteux
Mol. Hum. Reprod., 2017-07-01;0(0):1-12.
Applications: Bioassay -
Harnessing the natural inhibitory domain to control TNF? Converting Enzyme (TACE) activity in vivo
Sci Rep, 2016-12-16;6(0):35598.
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ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes.
Authors: Ejiofor a D Ezekwe, Chengyu Weng, Joseph A Duncan
Toxins, 2016-03-30;0(0):2072-6651.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation.
Authors: Lajoie L, Congy-Jolivet N, Bolzec A, Gouilleux-Gruart V, Sicard E, Sung H, Peiretti F, Moreau T, Vie H, Clemenceau B, Thibault G
J Immunol, 2013-12-13;192(2):741-51.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Canonical transforming growth factor-beta signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Authors: Ramdas V, McBride M, Denby L, Baker A
Am J Pathol, 2013-10-06;183(6):1885-96.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Bioassay -
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.
Authors: Al-Tamimi M, Tan CW, Qiao J, Pennings GJ, Javadzadegan A, Yong AS, Arthur JF, Davis AK, Jing J, Mu FT, Hamilton JR, Jackson SP, Ludwig A, Berndt MC, Ward CM, Kritharides L, Andrews RK, Gardiner EE
Blood, 2012-03-19;119(18):4311-20.
Species: Human
Sample Types: Whole Cells
Applications: Enzyme Assay -
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease.
Authors: Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y
Mol Neurodegener, 2011-10-06;6(0):69.
Species: Human
Sample Types: CSF
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Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity.
Authors: Reiss K, Cornelsen I, Husmann M
J. Biol. Chem., 2011-06-03;286(30):26931-42.
Species: Rabbit
Sample Types: Whole Cells
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Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Authors: Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G
Am. J. Pathol., 2007-09-14;171(5):1713-23.
Species: Human
Sample Types: Biofilm
Applications: Bioassay -
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Authors: Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA
Cancer Cell, 2006-07-01;10(1):39-50.
Species: Human
Sample Types: Protein
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