Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate
Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate Summary
Product Specifications
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
ES010
Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light. |
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Citations for Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms
Authors: J Alsolaiss, N Alomran, L Hawkins, NR Casewell
Toxins, 2022-12-20;15(1):.
Species: Snake
Sample Types: Venom
Applications: Bioassay -
ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non?redundantly to ADAM17
Authors: M Zatovicova, I Kajanova, M Takacova, L Jelenska, O Sedlakova, M Labudova, S Pastorekov
Oncology reports, 2022-12-16;49(2):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Physiological constraints dictate toxin spatial heterogeneity in snake venom glands
Authors: TD Kazandjian, BR Hamilton, SD Robinson, SR Hall, KE Bartlett, P Rowley, MC Wilkinson, NR Casewell, EAB Undheim
Bmc Biology, 2022-06-27;20(1):148.
Species: Snake
Sample Types: Venom
Applications: Bioassay -
Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin
Authors: L Kumar, J Planas-Igl, C Harms, S Kamboj, D Wright, J Klein-Seet, SK Sarkar
Sci Rep, 2020-11-26;10(1):20615.
Species: E. coli
Sample Types: Protein
Applications: Bioassay -
Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis
Authors: K Falkowski, E Bielecka, IB Thøgersen, O Boche?ska, K P?aza, M Kali?ska, L S?siadek, M Magoch, A P?cak, M Wi?niewska, N Gruba, M Wysocka, A Wojtysiak, M Brzezi?ska, K Sychowska, A Pejkovska, M Rehders, G Butler, CM Overall, K Brix, G Dubin, A Lesner, A Kozik, JJ Enghild, J Potempa, T Kantyka
Int J Mol Sci, 2020-06-19;21(12):.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Efficient protease based purification of recombinant matrix metalloprotease-1 in E. coli
Authors: L Kumar, W Colomb, J Czerski, CR Cox, SK Sarkar
Protein Expr. Purif., 2018-04-04;0(0):.
Applications: Enzyme Assay Substrate -
Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-? converting enzyme
Authors: JB Schaal, T Maretzky, DQ Tran, PA Tran, P Tongaonkar, CP Blobel, AJ Ouellette, ME Selsted
J. Biol. Chem., 2018-01-09;0(0):.
Applications: Bioassay -
Centrosomal protein 55 activates NF-?B signalling and promotes pancreatic cancer cells aggressiveness
Authors: T Peng, W Zhou, F Guo, HS Wu, CY Wang, L Wang, ZY Yang
Sci Rep, 2017-07-19;7(1):5925.
Species: Human
Sample Types: Protein
Applications: Enzyme Assay -
Fluid shear stress activates YAP1 to promote cancer cell motility
Authors: HJ Lee, MF Diaz, KM Price, JA Ozuna, S Zhang, EM Sevick-Mur, JP Hagan, PL Wenzel
Nat Commun, 2017-01-18;8(0):14122.
Species: Human
Sample Types: Cell Lysates
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Harnessing the natural inhibitory domain to control TNF? Converting Enzyme (TACE) activity in vivo
Sci Rep, 2016-12-16;6(0):35598.
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Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour
Open Biol, 2016-11-01;6(11):.
Species: Human
Sample Types: Cell Culture Supernates, Whole Cells
Applications: Bioassay -
Interdomain Contacts and the Stability of Serralysin Protease from Serratia marcescens.
Authors: Zhang L, Morrison A, Thibodeau P
PLoS ONE, 2015-09-17;10(9):e0138419.
Species: Bacteria - Serratia marcescens
Sample Types: Protein
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Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects.
Authors: Duan J, Rapti M, Tsigkou A, Lee M
PLoS ONE, 2015-08-26;10(8):e0136384.
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Sequential Amyloid-beta Degradation by the Matrix Metalloproteases MMP-2 and MMP-9.
Authors: Hernandez-Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, Ghiso J
J Biol Chem, 2015-04-20;290(24):15078-91.
Species: Human
Sample Types: Protein
Applications: Enzyme Assay -
Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection.
Authors: Zhu, Wenhan, Tao, Lili, Quick, Marsha L, Joyce, Johanna, Qu, Jie-Ming, Luo, Zhao-Qin
PLoS Pathog, 2015-03-04;11(3):e1004704.
Species: Mouse
Sample Types: Whole Cells
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Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.
Authors: Butterworth, Michael, Zhang, Liang, Liu, Xiaoning, Shanks, Robert M, Thibodeau, Patrick
PLoS ONE, 2014-06-25;9(6):e100313.
Species: Bacteria - Pseudomonas aeruginosa
Sample Types: Protein
Applications: Bioassay -
ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation.
Authors: Lajoie L, Congy-Jolivet N, Bolzec A, Gouilleux-Gruart V, Sicard E, Sung H, Peiretti F, Moreau T, Vie H, Clemenceau B, Thibault G
J Immunol, 2013-12-13;192(2):741-51.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse.
Authors: Ramani V, Sanderson R
Matrix Biol, 2013-10-18;35(0):215-22.
Species: Human
Sample Types: Whole Cells
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Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.
Authors: Hayes C, Dey D, Palavicini J, Wang H, Patkar K, Minond D, Nefzi A, Lakshmana M
BMC Med, 2013-03-26;11(0):81.
Species: Hamster
Sample Types: Whole Cells
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Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.
Authors: Ingvarsen S, Porse A, Erpicum C, Maertens L, Jurgensen H, Madsen D, Melander M, Gardsvoll H, Hoyer-Hansen G, Noel A, Holmbeck K, Engelholm L, Behrendt N
J Biol Chem, 2013-02-14;288(15):10195-204.
Species: Mouse
Sample Types: Protein
Applications: Enzyme Assay -
Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer.
Authors: Fujisawa T, Rubin B, Suzuki A, Patel PS, Gahl WA, Joshi BH, Puri RK
PLoS ONE, 2012-04-20;7(4):e34437.
Species: Human
Sample Types: Whole Cells
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IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition.
Authors: Walsh L, Damjanovski S
Cell Commun Signal, 2011-05-02;9(1):10.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay -
An orally available small imidazolium salt ameliorates inflammation and fibrosis in a murine model of cholestasis.
Authors: Ding Z, Kng Y, Yang H, Ke Z, Zhuo L
Lab. Invest., 2011-02-21;91(5):752-63.
Species: Mouse
Sample Types: Tissue Homogenates
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Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Authors: Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A
Blood, 2009-03-03;113(19):4799-809.
Species: Mouse
Sample Types: Cell Lysates
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Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
Authors: Yamashita Y, Kawashima I, Yanai Y, Nishibori M, Richards JS, Shimada M
Endocrinology, 2007-09-27;148(12):6164-75.
Species: Porcine
Sample Types: Cell Lysates
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The shedding activity of ADAM17 is sequestered in lipid rafts.
Authors: Tellier E, Rebsomen L
Exp. Cell Res., 2006-09-05;312(20):3969-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
FAQs
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What other wavelengths would be suitable for the excitation and emission for this peptide substrate?
We have only tested this at an excitation wavelength of 320 nm and emission wavelength at 405 nm; please see the following reference for the excitation and emission spectra of the unquenched Mca-Pro-Leu peptide:
C.G. Knight, et. al, 1992. FEBS Letters 296:263-266
https://doi.org/10.1016/0014-5793(92)80300-6.
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