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M62812

Catalog #: 5705
2 Citations Datasheet / COA / SDS

Discontinued Product

5705 has been discontinued.
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M62812 | CAS No. 613263-00-6 | Toll-like Receptor Inhibitors
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Description: TLR-4 inhibitor

Chemical Name: 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Technical Data

M.Wt:
330.23
Formula:
C13H11N3OS.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
613263-00-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice.
    Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, Kato Y, Hosaka Y, Furusako S
    Eur. J. Pharmacol., 2007-06-05;569(3):237-43.

Product Datasheets

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Citations for M62812

The citations listed below are publications that use Tocris products. Selected citations for M62812 include:

2 Citations: Showing 1 - 2

  1. Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.
    Authors: Jing Et al.
    Adv Sci (Weinh)  2020;7:2000771
  2. TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
    Authors: Nara Et al.
    Sci Rep  2020;10:17451

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