Home / CCK2 Receptor Antagonists / LY 288513

LY 288513

Catalog #: 1524
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LY 288513 | CAS No. 147523-65-7 | CCK2 Receptor Antagonists
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Description: Selective CCK2 antagonist

Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.

Technical Data

M.Wt:
436.3
Formula:
C22H18BrN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
147523-65-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Eli Lilly and Company

Background References

  1. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
    Wen D, Ma CL, Zhang YJ, Meng YX, Ni ZY, Li SJ, Cong B
    BMC Neurosci, 2012;13(0):63.
  2. CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain DA neurons.
    Rasmussen
    Ann.N.Y.Acad.Sci., 1994;713:300
  3. Central nervous system characterization of the new cholecystokininB antagonist LY288513.
    Helton et al.
    Pharmacol.Biochem.Behav., 1996;53:493
  4. Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain DA neurons.
    Rasmussen et al.
    J.Pharmacol.Exp.Ther., 1992;264:480

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Citation for LY 288513

The citations listed below are publications that use Tocris products. Selected citations for LY 288513 include:

1 Citation: Showing 1 - 1

  1. Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence.
    Authors: Wen Et al.
    Front Endocrinol (Lausanne)  2012;13:63

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